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S4317
SB 431542 hydrate
≥98% (HPLC), powder, inhibits activation of SMAD proteins
Synonym(s):
4-(5-Benzol[1,3]dioxol-5-yl-4-pyrldin-2-yl-1H-imidazol-2-yl)-benzamide hydrate, 4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-benzamide hydrate, 4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]-benzamide hydrate
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5 MG
CLP 277,000
About This Item
Empirical Formula (Hill Notation):
C22H16N4O3 · xH2O
CAS Number:
Molecular Weight:
384.39 (anhydrous basis)
MDL number:
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
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Product Name
SB 431542 hydrate, ≥98% (HPLC), powder
Assay
≥98% (HPLC)
form
powder
solubility
DMSO: soluble 10 mg/mL
H2O: insoluble
originator
GlaxoSmithKline
storage temp.
−20°C
SMILES string
O.NC(=O)c1ccc(cc1)-c2nc(-c3ccc4OCOc4c3)c([nH]2)-c5ccccn5
InChI
1S/C22H16N4O3.H2O/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17;/h1-11H,12H2,(H2,23,27)(H,25,26);1H2
InChI key
WQUIJVKNPYBZOF-UHFFFAOYSA-N
Application
Biochem/physiol Actions
Potent and selective inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors.
Features and Benefits
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Legal Information
Sold for research purposes under agreement from GlaxoSmithKline
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Protocols
Step-by-step culture protocols for neural stem cell culture including NSC isolation, expansion, differentiation and characterization.
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If not reconstituted for how long can I store the vial?
1 answer-
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How long can I store the reconstituted compound in the freezer -20 degrees? i have one that was aliquoted 4 years ago. Is it still ok to use it ?
1 answer-
It is recommended, following reconstitution, to aliquot and freeze -20°C. The stock solutions are stable for up to 6 months at -20°C. The quality of solutions stored frozen for extended periods has not been evaluated. The end user would have to determine suitability. Any color change, cloudiness, or particulate matter present upon thawing would be a visual indicator of degradation.
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