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S1069

(S)-SNAP-5114

≥98% (HPLC), GABA transport inhibitor, solid

Synonym(s):

(S)-1-[2-[Tris(4-methoxyphenyl)methoxy]ethyl]-3-piperidinecarboxylic acid

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CLP 120,000

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CLP 436,000

CLP 120,000

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About This Item

Empirical Formula (Hill Notation):
C30H35NO6
CAS Number:
157604-55-2
Molecular Weight:
505.60
UNSPSC Code:
12352200
PubChem Substance ID:
329824443
NACRES:
NA.77
MDL number:
MFCD06411702

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Product Name

(S)-SNAP-5114, ≥98% (HPLC), solid

SMILES string

COc1ccc(cc1)C(OCCN2CCC[C@@H](C2)C(O)=O)(c3ccc(OC)cc3)c4ccc(OC)cc4

InChI key

VDLDUZLDZBVOAS-QFIPXVFZSA-N

InChI

1S/C30H35NO6/c1-34-26-12-6-23(7-13-26)30(24-8-14-27(35-2)15-9-24,25-10-16-28(36-3)17-11-25)37-20-19-31-18-4-5-22(21-31)29(32)33/h6-17,22H,4-5,18-21H2,1-3H3,(H,32,33)/t22-/m0/s1

assay

≥98% (HPLC)

form

solid

optical activity

[α]/D -8 to -13°, c = 1 in chloroform-d

color

white

solubility

DMSO: >5 mg/mL
H2O: insoluble

storage temp.

−20°C

Quality Level

100

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This Item
S5192SML0980S7809
(S)-SNAP-5114 ≥98% (HPLC), solid

Sigma-Aldrich

S1069

(S)-SNAP-5114

SB 222200 ≥98% (HPLC), solid

Sigma-Aldrich

S5192

SB 222200

CYM51010 ≥98% (HPLC)

Sigma-Aldrich

SML0980

CYM51010

SKF-96365 ≥98% (HPLC), solid

Sigma-Aldrich

S7809

SKF-96365

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

solid

form

solid

form

powder

form

solid

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

solubility

DMSO: >5 mg/mL, H2O: insoluble

solubility

DMSO: soluble ~28 mg/mL, H2O: insoluble

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: >20 mg/mL, H2O: >20 mg/mL

color

white

color

light yellow

color

white to beige

color

white

Biochem/physiol Actions

GABA transport inhibitor, showing selectivity for GAT-3 and GAT-2.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GABA Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000502230
0000502229
0000502230
0000502229
0000339002

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Maria Ek Lie et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 38(1), 166-173 (2017-11-18)
Brain ischemia triggers excitotoxicity and cell death, yet no neuroprotective drugs have made it to the clinic. While enhancing GABAergic signaling to counterbalance excitotoxicity has shown promise in animal models, clinical studies have failed. Blockade of GABA transporters (GATs) offers
Jonas M Fuks et al.
PLoS pathogens, 8(12), e1003051-e1003051 (2012-12-14)
During acute infection in human and animal hosts, the obligate intracellular protozoan Toxoplasma gondii infects a variety of cell types, including leukocytes. Poised to respond to invading pathogens, dendritic cells (DC) may also be exploited by T. gondii for spread
N O Dalby
Neuropharmacology, 39(12), 2399-2407 (2000-09-07)
The present study examines the effect of tiagabine (a selective inhibitor of GABA transporter 1, GAT-1), SNAP-5114 (a semi-selective inhibitor of rat GAT-3/mouse GAT4) and NNC 05-2045 (a non-selective GABA uptake inhibitor) in modulating GABA levels in the hippocampus and
Adam C Lu et al.
eLife, 9 (2020-09-10)
Absence seizures result from 3 to 5 Hz generalized thalamocortical oscillations that depend on highly regulated inhibitory neurotransmission in the thalamus. Efficient reuptake of the inhibitory neurotransmitter GABA is essential, and reuptake failure worsens human seizures. Here, we show that
L A Borden
Neurochemistry international, 29(4), 335-356 (1996-10-01)
gamma-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain. GABA is cleared from the synaptic cleft by specific, high-affinity, sodium- and chloride-dependent transporters, which are thought to be located on presynaptic terminals and surrounding glial cells. While
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