M9019
IgG3, Lambda from murine myeloma
clone Y5606, purified immunoglobulin, buffered aqueous solution
Synonym(s):
Mouse IgG3-λ
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About This Item
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biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
clone
Y5606, monoclonal
form
buffered aqueous solution
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
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General description
IgG (Immunoglobulin G) are the most common Immunoglobulin′s isotype in blood, lymph, cerebrospinal and peritoneal fluids and serve as key players in the humoral immune response. IgG include four subclasses (IgG1, IgG2, IgG3, and IgG4), consist of a variable Fab fragment (which includes the antibody recognition site) and a conserved Fc fragment.
Application
IgG3, λ from murine myeloma is suitable as isotype control in immunohistochemistry of formalin-fixed, paraffin-embedded sections and in FACS.
IgG3, Lambda from murine myeloma antibody has been used in Fluorescent activated cell sorting (FACS).
Biochem/physiol Actions
IgG antibody subtype is the most abundant of serum immunoglobulins of the immune system. It is secreted by B cells and is found in blood and extracellular fluids and provides protection from infections caused by bacteria, fungi and viruses. Maternal IgG is transferred to fetus through the placenta that is vital for immune defense of the neonate against infections.
Physical form
Solution in 0.02 M Tris buffered saline, pH 8.0, containing 0.02% sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Nicholas R Forsyth et al.
Cloning and stem cells, 8(1), 16-23 (2006-03-31)
Human embryonic stem cells (hESC) have great potential in regenerative medicine, provided that culture systems are established that maintain genomic integrity. Here we describe a comparison of the effects of culture in either physiologic oxygen (2%) or room oxygen (21%)
Nurlaely Mida Rachmawati et al.
International immunology, 25(2), 117-128 (2012-10-19)
Stimulation of Toll-like receptor 4 (TLR4) induces not only innate but also adaptive immune responses, and has been suggested to exert adjuvant effects. Additional to such positive effects, pre-stimulation of TLR4 induces endotoxin tolerance where animals are unresponsive to subsequent
Tracy Goodpaster et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 56(4), 347-358 (2007-12-12)
Fibroblasts are critical for tissue homeostasis, and their inappropriate proliferation and activation can result in common and debilitating conditions including fibrosis and cancer. We currently have a poor understanding of the mechanisms that control the growth and activation of fibroblasts
Systematic analysis of ATG13 domain requirements for autophagy induction
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Autophagy, 14(5), 743-763 (2018)
S Hashira et al.
Pediatrics international : official journal of the Japan Pediatric Society, 42(4), 337-342 (2000-09-15)
Maternal immunoglobulin G (IgG), transferred across the placenta to the fetus during intrauterine life, is an important component of the neonatal immunological defence mechanisms against infection. There is controversy with respect to differences in placental transfer of the different IgG
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