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H7509

Sigma-Aldrich

(Hydroxypropyl)methyl cellulose

viscosity 2,600-5,600 cP, 2 % in H2O(20 °C)(lit.)

Synonym(s):

2-Hydroxypropyl methyl cellulose ether

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About This Item

CAS Number:
MDL number:
UNSPSC Code:
12352201
NACRES:
NA.25

biological source

plant

form

powder

mol wt

~86 kDa

color

white to off-white

viscosity

2,600-5,600 cP, 2 % in H2O(20 °C)(lit.)

solubility

water: 10 mg/mL, clear to very slightly hazy, colorless

storage temp.

room temp

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General description

(Hydroxypropyl)methylcellulose (HPMC) is a water-soluble polymer derived from cellulose. This polysaccharide forms colloids when dissolved in water. HPMC is a hydrocolloid produced artificially from natural substances. It consists of 28-30% methoxyl content and 7-12% of hydroxypropoxyl content.

Application

(Hydroxypropyl)methyl cellulose (HPMC) has been used:
  • as a viscosity modifier in the preparation of printable ink
  • as a viscosifier in the preparation of hydroxyapatite (HAP) suspension
  • in the preparation of HPMC gels and composite gels

Thickener for aqueous and non-aqueous systems, clear films with grease resistance, binders, lubricants, steric stabilizer and water retention aid.

Biochem/physiol Actions

(Hydroxypropyl)methylcelluloses (HPMCs) act as suspension aids, surfactants, lubricants, protective colloids, and emulsifiers. Additionally, solutions of these polymers show thermal gelation properties. They are generally used as binders, thickeners, film formers, and water retention agents. HPMC also elicits surface-active properties.

Features and Benefits

Dissolves in water, undergoes reversible gelation upon heating, non-ionic, does not complex with ionic species and is surface active and enzyme resistant. Solutions are pseudoplastic.

Other Notes

To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Alexandre Goyon et al.
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The determination of mAb critical quality attributes (CQA) is crucial for their successful application in health diseases. A generic CZE method was developed for the high-resolution separation of various mAb charge variants, which are often recognized as important CQA. A
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Infection and immunity, 82(5), 1850-1859 (2014-02-26)
Tuberculosis remains a major worldwide epidemic because of its sole etiological agent, Mycobacterium tuberculosis. Ethionamide (ETH) is one of the major antitubercular drugs used to treat infections with multidrug-resistant M. tuberculosis strains. ETH is a prodrug that requires activation within
Bernd Moritz et al.
Electrophoresis, 38(24), 3136-3146 (2017-09-10)
CZE is a well-established technique for charge heterogeneity testing of biopharmaceuticals. It is based on the differences between the ratios of net charge and hydrodynamic radius. In an extensive intercompany study, it was recently shown that CZE is very robust
Mylène Tajan et al.
Nature communications, 12(1), 366-366 (2021-01-16)
Many tumour cells show dependence on exogenous serine and dietary serine and glycine starvation can inhibit the growth of these cancers and extend survival in mice. However, numerous mechanisms promote resistance to this therapeutic approach, including enhanced expression of the de

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