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EDFS

Sigma-Aldrich

Ethylenediaminetetraacetic acid iron(III) sodium salt

powder

Synonym(s):

EDTA iron(III) sodium salt, Edathamil, Komplexon II

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About This Item

Linear Formula:
C10H12N2NaFeO8
CAS Number:
Molecular Weight:
367.05
EC Number:
MDL number:
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77

biological source

synthetic (organic)

Quality Level

Agency

suitable for SM 5210

form

powder

composition

Iron, 13.7-18.7% ICP
Sodium, 5.6-7.9% ICP

reaction suitability

reagent type: chelator

concentration

≥67.5% (EDTA titration)

pH

4.5

mp

80 °C

solubility

water: 50 mg/mL, clear to slightly hazy, yellow to brown

storage temp.

room temp

SMILES string

[Na+].[Fe+3].[O-]C(=O)CN(CCN(CC([O-])=O)CC([O-])=O)CC([O-])=O

InChI

1S/C10H16N2O8.Fe.Na/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;/q;+3;+1/p-4

InChI key

MKWYFZFMAMBPQK-UHFFFAOYSA-J

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Application

Used to eliminate enzyme inhibition by traces of heavy metals, and to inhibit enzymes that require divalent cations as cofactors. Iron-EDTA enhances damage due to reactive oxygen species, such as depletion of reduced glutathione, formation of methemoglobin, and lipid peroxidation.

Legal Information

Komplexon is a trademark of CU Chemie Uetikon AG

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Natasha T Forester et al.
Molecular plant-microbe interactions : MPMI, 32(10), 1324-1335 (2019-05-21)
In ascomycetes and basidiomycetes, iron-responsive GATA-type transcriptional repressors are involved in regulating iron homeostasis, notably to prevent iron toxicity through control of iron uptake. To date, it has been unknown whether this iron regulator contributes toward mutualistic endosymbiosis of microbes
Barbara Troesch et al.
The Journal of nutrition, 141(5), 822-827 (2011-03-25)
The absorption profile of iron fortificants may be a determinant of their ability to generate nontransferrin-bound iron (NTBI) and, thus, their potential safety. Ferrous iron may be absorbed more rapidly than chelated ferric iron, but differences at the fortification level
Tarun Gera et al.
The American journal of clinical nutrition, 96(2), 309-324 (2012-07-05)
The utility of iron fortification of food to improve iron deficiency, anemia, and biological outcomes is not proven unequivocally. The objectives were to evaluate 1) the effect of iron fortification on hemoglobin and serum ferritin and the prevalence of iron
Catherine W Macharia-Mutie et al.
The Journal of nutrition, 142(9), 1756-1763 (2012-07-20)
Few studies have evaluated the impact of fortification with iron-rich foods such as amaranth grain and multi-micronutrient powder (MNP) containing low doses of highly bioavailable iron to control iron deficiency anemia (IDA) in children. We assessed the efficacy of maize
Monica N Orozco et al.
Annals of nutrition & metabolism, 60(2), 108-114 (2012-03-15)
In any context of iron supplementation in the prenatal prophylaxis or therapeutic dosage range, a large amount will remain unabsorbed and pass through the intestinal tract into the colonic digesta possibly causing increased oxidation. To compare the generation of fecal

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