E5156

Epinastine hydrochloride

≥98% (HPLC), H1 histamine receptor antagonist, solid

• Synonym(s): 9,13b-Dihydro-1H-dibenz[cf]imidazo[1,5-a]azepine hydrochloride, WAL-801Cl
• Empirical Formula (Hill Notation): C₁₆H₁₅N₃ · HCl
• CAS Number: 108929-04-0
• Molecular Weight: 285.77
• UNSPSC Code: 12352200
• PubChem Substance ID: 24894608
• NACRES: NA.77
• MDL number: MFCD00933434
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: desiccated

Properties

• Product Name: Epinastine hydrochloride, ≥98% (HPLC), solid
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• storage condition: desiccated
• color: white
• solubility: H₂O: 38 mg/mL
• originator: Boehringer Ingelheim
• storage temp.: 2-8°C
• SMILES string: Cl[H].NC1=NCC2N1c3ccccc3Cc4ccccc24
• InChI: 1S/C16H15N3.ClH/c17-16-18-10-15-13-7-3-1-5-11(13)9-12-6-2-4-8-14(12)19(15)16;/h1-8,15H,9-10H2,(H2,17,18);1H
• InChI key: VKXSGUIOOQPGAF-UHFFFAOYSA-N
• Gene Information: human ... HRH1(3269)

Description

General description

Epinastine has antihistamine functions. In mast cells, it may modulate cytokine and chemokine production. In dendritic cells, it controls T helper cell mediated immune response. Epinastine hydrochloride does not traverse the brain barrier. Oral dosage of epinastine hydrochloride is prescribed for children with sleep-disordered breathing (SDB) and nasal inflammation. Ophthalmic solution of epinastine is effective for allergic conjunctivitis.

Biochem/physiol Actions

Epinastine hydrochloride is a non-sedating H1 histamine receptor antagonist.

Features and Benefits

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Codes: H301
• Precautionary Statements: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• PPE (personal protective equipment): Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges