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C8249

Cardamonin

≥98% (HPLC),  glycogen synthase kinase 3 (GSK3) inhibitor, powder

Synonym(s):

(2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-phenyl-2-propen-1-one, (8CI); Alpinetin chalcone, (E)-2′,4′-Dihydroxy-6′-methoxy-chalcone

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Pack SizeSKUAvailabilityPrice
5 mg
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CLP 140,000
25 mg
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CLP 566,000

About This Item

Empirical Formula (Hill Notation):
C16H14O4
CAS Number:
19309-14-9
Molecular Weight:
270.28
UNSPSC Code:
12352200
PubChem Substance ID:
329775163
NACRES:
NA.77
MDL number:
MFCD00238554
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100

CLP 140,000

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Product Name

Cardamonin, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

light yellow to dark brown

solubility

DMSO: ≥20 mg/mL

storage temp.

room temp

SMILES string

O=C(/C=C/C1=CC=CC=C1)C2=C(O)C=C(O)C=C2OC

InChI

1S/C16H14O4/c1-20-15-10-12(17)9-14(19)16(15)13(18)8-7-11-5-3-2-4-6-11/h2-10,17,19H,1H3/b8-7+

InChI key

NYSZJNUIVUBQMM-BQYQJAHWSA-N

Application

Cardamonin has been used as a glycogen synthase kinase 3 (GSK3) inhibitor to study its effects on β-catenin loss and gain-of-function in human preimplantation embryos.
Cardamonin has been used as a standard in high performance liquid chromatography (HPLC) to analyze phenolic compounds in acacia honey samples.

Biochem/physiol Actions

Cardamonin is a calchone from Aplinia species (zingiberaceous plant species).
Cardamonin is a calchone from Aplinia species (zingiberaceous plant species). Cardamonin inhibits pigmentation in melanocytes through suppression of Wnt/b-catenin signaling pathway. Cardamonin suppressed Wnt/b-catenin signaling by a mechanism involving proteasome-mediated degradation of b-catenin (GSK-3b-independent pathway). Research has shown that Cardamonin possesses anti-inflammatory activity via suppression of NF-kB nuclear translocation and Ik-Ba phosphorylation.

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This Item
SML0927SML1450D6571
Cardamonin ≥98% (HPLC)

Sigma-Aldrich

C8249

Cardamonin

Diapocynin ≥98% (HPLC)

Sigma-Aldrich

SML0927

Diapocynin

Isobavachalcone ≥98% (HPCE)

Sigma-Aldrich

SML1450

Isobavachalcone

3′,4′-Dimethoxyflavone

Sigma-Aldrich

D6571

3′,4′-Dimethoxyflavone

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPCE)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

room temp

storage temp.

room temp

storage temp.

−20°C

storage temp.

room temp

solubility

DMSO: ≥20 mg/mL

solubility

DMSO: 2 mg/mL, clear (warmed)

solubility

DMSO: 5 mg/mL, clear (warmed)

solubility

DMSO: ≥20 mg/mL

color

light yellow to dark brown

color

white to beige

color

white to beige

color

white to off-white

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000392125
0000392125
0000160959
0000126830

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Global Trade Item Number

SKUGTIN
C8249-25MG04061832631882
C8249-5MG04061833521960

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