This product has not been tested for in vivo use. The material is soluble at 50 mg/mL in 1N HCl. The stock solution would require sterile filtration before further dilution with a sterile buffer or medium.
C6506
4-Chloro-DL-phenylalanine
5-HT synthesis inhibitor, solid
Synonym(s):
PCP, PCPA
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| Size/SKU | Availability | Price |
|---|---|---|
5 g | Check Cart for Availability | CLP 118,000 |
25 g | Check Cart for Availability | CLP 441,000 |
About This Item
Linear Formula:
ClC6H4CH2CH(NH2)CO2H
CAS Number:
Molecular Weight:
199.63
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352209
EC Number:
231-051-9
MDL number:
Product Name
4-Chloro-DL-phenylalanine,
form
solid
Quality Segment
greener alternative product score
old score: 2
new score: 1
Find out more about DOZN™ Scoring
greener alternative product characteristics
Less Hazardous Chemical Syntheses
Designing Safer Chemicals
Design for Energy Efficiency
Learn more about the Principles of Green Chemistry.
sustainability
Greener Alternative Product
mp
>240 °C (dec.) (lit.)
greener alternative category
storage temp.
room temp
SMILES string
NC(Cc1ccc(Cl)cc1)C(O)=O
InChI
1S/C9H10ClNO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13)
InChI key
NIGWMJHCCYYCSF-UHFFFAOYSA-N
Gene Information
human ... TPH1(7166), TPH2(121278)
General description
We are committed to bringing you Greener Alternative Products, which adhere to one of the four categories of Greener Alternatives . This product belongs to category of Re-engineered products, showing key improvements in Green Chemistry Principles "Less Hazardous Chemical Syntheses", "Designing Safer Chemicals" and "Design for Energy Efficiency". Click here to view its DOZN scorecard.
Application
4-Chloro-DL-phenylalanine has been used:
- as tryptophan hydroxylase 1 (TPH1) inhibitor to treat kras+ male zebrafish
- to induce insomnia in rat models
- used to treat embryos to examine its effect on serotonin
- for the selection of Enterococcus faecalis transformants with pESentA32 plasmid
- to feed flies to explore serotonin effect
Biochem/physiol Actions
Tryptophan hydroxylase inhibitor.
4-Chloro-DL-phenylalanine (PCPA) is an inhibitor of 5-hydroxytrytamine (5-HT) synthesis. It helps to improve the inflammation of lung tissue and remodeling pulmonary artery. PCPA can reduce the expression of tryptophan hydroxylase 1 (TPH1), matrix metalloproteinase (MMP) and pro-inflammatory factors.
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This Item | |||
|---|---|---|---|
| Quality Level 100 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| form solid | form powder | form solid | form - |
| Gene Information human ... TPH1(7166), TPH2(121278) | Gene Information - | Gene Information - | Gene Information - |
| storage temp. room temp | storage temp. −20°C | storage temp. −20°C | storage temp. - |
| greener alternative category | greener alternative category | greener alternative category | greener alternative category |
| greener alternative product score old score: 2 | greener alternative product score old score: 56 | greener alternative product score old score: 51 | greener alternative product score old score: 2 |
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Skin Sens. 1
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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For in vivo experiment, does this have to be dissolved in 1N HCL?
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