C4187
Cyanoborohydride Coupling Buffer
Synonym(s):
Coupling buffer
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| Size/SKU | Availability | Price |
|---|---|---|
500 mL | Check Cart for Availability | CLP 322,000 |
1 L | Check Cart for Availability | CLP 497,000 |
About This Item
NACRES:
NA.56
UNSPSC Code:
12161700
CLP 322,000
Check Cart for Availability
form
liquid
Quality Segment
reaction suitability
reagent type: reductant
technique(s)
affinity chromatography: suitable
application(s)
life science and biopharma
storage temp.
2-8°C
Application
A ready-to-use reagent used to couple amine ligands to aldehyde functional groups. The coupling buffer reaction is a reductive amination of the intermediate Schiff′s base to a stable C−N bond.
Cyanoborohydride Coupling Buffer is used in affinity chromatography, protein chromatography, activated/functionalized matrices and synthetic reagents. Cyanoborohydride has been used to inform a safe and effective gene-transfer system targeting hepatocytes as well as to develop a method for targeted delivery of anticancer therapeutics to cancer cells in hypoxic areas.
Cyanoborohydride Coupling Buffer has been used:
- in coupling reactions between amines and glutaraldehyde
- to reduce hydrazone bond to a stable hydrazide bond
- as a component in oligonucleotide reaction mixture for coverslips functionalization
Biochem/physiol Actions
Cyanoborohydride Coupling Buffer is a reagent suitable for reductive amination processes, that contributes to transformation of simple alcohols into more complex amines. It is used in the conversion of Schiff base, by reducing it, to form a secondary amine without affecting aldehyde groups on the support.
Preparation Note
0.02 M sodium phosphate, pH 7.5, containing 0.2 M sodium chloride and 3.0 g/L sodium cyanoborohydride
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This Item | |||
|---|---|---|---|
| technique(s) affinity chromatography: suitable | technique(s) - | technique(s) - | technique(s) ELISA: suitable |
| Quality Level 200 | Quality Level 100 | Quality Level 300 | Quality Level 200 |
| form liquid | form liquid | form liquid | form liquid |
| application(s) life science and biopharma | application(s) - | application(s) diagnostic assay manufacturing | application(s) - |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| reaction suitability reagent type: reductant | reaction suitability - | reaction suitability - | reaction suitability - |
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 2
Storage Class
12 - Non Combustible Liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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