C0913
Complement C2 deficient serum human
for complement assays
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| Size/SKU | Availability | Price |
|---|---|---|
1 mL | Check Cart for Availability | CLP 249,000 |
About This Item
Form:
liquid
Biological source:
human
CLP 249,000
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Application
C2 is a critical protease for compliment activation, which supports bacterial killing via phagocytes. C2 can be used in research to explore the mechanisms by which bacterial pathogens evade detection by the compliment system. One such mechanism by the bacteria Pseudomonas aeruginosa, uses the alkaline protease (AprA) to degrade and cleave C2 which ultimately interferes with the classical and lectin pathways. Research has shown that C2 deficiency results in an increased risk of infection by Streptococcus pyogenes through impaired phaogocytosis and neutrophil dependent killing.
Biochem/physiol Actions
Physical form
Supplied as a solution in PBS, pH 7.2
Analysis Note
C2 is depleted by immunoadsorption method as judged by a highly sensitive hemolytic assay and Ouchterlony immunodiffusion method.
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
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This Item | |||
|---|---|---|---|
| description for complement assays | description for complement assays | description ≥3000 C3H50 units/mg (using C3 deficient serum) | description ≥90% (SDS-PAGE), >100,000 C5H50 units/mg protein |
| technique(s) activity assay: suitable | technique(s) activity assay: suitable | technique(s) activity assay: suitable | technique(s) activity assay: suitable |
| biological source human | biological source human | biological source human | biological source human serum |
| form liquid | form liquid | form solution | form solution |
| shipped in dry ice | shipped in dry ice | shipped in dry ice | shipped in dry ice |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. |
| storage temp. −70°C | storage temp. −70°C | storage temp. −70°C | storage temp. −70°C |
Storage Class
12 - Non Combustible Liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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