A9611

Atipamezole

≥98% (HPLC), α2-adrenoceptor antagonist, powder

• Synonym(s): 4-(2-Ethyl-2,3-dihydro-1H-inden-2-yl)-1H-Imidazole, Antisedan, MPV 1248
• Empirical Formula (Hill Notation): C₁₄H₁₆N₂
• CAS Number: 104054-27-5
• Molecular Weight: 212.29
• UNSPSC Code: 12352200
• PubChem Substance ID: 329771055
• NACRES: NA.77
• MDL number: MFCD00864502
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Product Name: Atipamezole, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to brown
• solubility: DMSO: ≥30 mg/mL
• storage temp.: room temp
• SMILES string: CCC1(Cc2ccccc2C1)c3c[nH]cn3
• InChI: 1S/C14H16N2/c1-2-14(13-9-15-10-16-13)7-11-5-3-4-6-12(11)8-14/h3-6,9-10H,2,7-8H2,1H3,(H,15,16)
• InChI key: HSWPZIDYAHLZDD-UHFFFAOYSA-N

Description

General description

Atipamezole has an imidazole structure and gets localized in the central nervous system on administration.[1]

Application

Atipamezole has been used as a α2-adrenoceptor antagonist in mesencephalic trigeminal nucleus (MTN) neurons,[2] CD4+ T-lymphocyte[3] and human embryonic kidney (HEK293) membrane preparation.

Biochem/physiol Actions

Atipamezole elicits affinity towards adrenoreceptor subtypes namely α2A, α2B and α2C. High levels of atipamezole impairs cognitive functions. It also reverses the adrenoreceptor agonist functionalities.[1] Atipamezole shows no affinity towards muscarinic[1] and dopamine or neurotransmitter receptors.[4] Atipamezole when used along with morphine elicits antinociceptive effects.[5]

Atipamezole is a selective α₂ adrenergic blocker. Atipamezole is more potent than yohimbine; it is very selective for α₂ adrenergic vs α₁ sites, but not selelctive for α₂ subtypes.

Atipamezole is a selective α₂ adrenergic blocker; neutral antagonist

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the α2-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable