This product is a research grade chemical and not a pharmaceutical product. While the same active enantiomer (R-(−)-apomorphine) is an approved medicine, it is not manufactured, packaged, or regulated as a clinical dosage form, so it should not be used in humans.
A4393
R-(−)-Apomorphine hydrochloride hemihydrate
calcined, ≥98% (with NaOH, titration)
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About This Item
Linear Formula:
C17H17NO2 · HCl · 1/2H2O
CAS Number:
Molecular Weight:
312.79
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352210
EC Number:
206-243-0
MDL number:
Assay:
≥98% (with NaOH, titration)
Form:
calcined, (Powder to Crystalline Powder)
Storage condition:
protect from light, under inert gas
Pricing and availability is not currently available.
Quality Segment
assay
≥98% (with NaOH, titration)
form
calcined, (Powder to Crystalline Powder)
storage condition
protect from light, under inert gas
color
white to gray
mp
285-287 °C (lit.)
solubility
H2O: ~10 mg/mL, clear, yellow-green
SMILES string
Cl[H].Cl[H].[H]O[H].[H][C@]12Cc3ccc(O)c(O)c3-c4cccc(CCN1C)c24.[H][C@]56Cc7ccc(O)c(O)c7-c8cccc(CCN5C)c68
InChI
1S/2C17H17NO2.2ClH.H2O/c2*1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12;;;/h2*2-6,13,19-20H,7-9H2,1H3;2*1H;1H2/t2*13-;;;/m11.../s1
InChI key
CXWQXGNFZLHLHQ-DPFCLETOSA-N
Gene Information
human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816)
Application
R-(-)-Apomorphine hydrochloride hemihydrate has been used as a dopamine receptor agonist to study its effects of rotational behavior in rat models of Parkinson′s disease.[1]
Biochem/physiol Actions
R-(−)-Apomorphine acts as a non-selective D1 and D2 dopamine receptor agonist. It shows therapeutic effects against Parkinson′s disease and male erectile dysfunction. R-(−)-Apomorphine also shows neuroprotective, radical scavenging, and emetic effects. Apomorphine stimulates the brain chemoreceptor trigger zone. It stimulates the chemoreceptor trigger zone in the brain.
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This Item | |||
|---|---|---|---|
| assay ≥98% (with NaOH, titration) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay - |
| form calcined, (Powder to Crystalline Powder) | form solid | form solid | form solid |
| Quality Level 200 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage condition protect from light, under inert gas | storage condition desiccated, under inert gas | storage condition desiccated, under inert gas | storage condition under inert gas |
| solubility H2O: ~10 mg/mL, clear, yellow-green | solubility DMSO: ~14 mg/mL, H2O: >5 mg/mL | solubility DMSO: >20 mg/mL, H2O: ≥5 mg/mL | solubility H2O: 22 mg/mL at ~60 °C |
| color white to gray | color - | color white | color white |
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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