92243

Cholesteryl N-(2-dimethylaminoethyl)carbamate

≥98% (TLC)

• Synonym(s): 3β-{N-[2-(Dimethylamino)ethyl]carbamoyl}cholesterol, DC-Chol
• Empirical Formula (Hill Notation): C₃₂H₅₆N₂O₂
• CAS Number: 137056-72-5
• Molecular Weight: 500.80
• UNSPSC Code: 12352211
• PubChem Substance ID: 329769879
• NACRES: NA.85

Properties

• Quality Segment: 100
• assay: ≥98% (TLC)
• form: powder or crystals
• functional group: ester
• storage temp.: −20°C
• SMILES string: CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4CC(CC[C@]4(C)[C@H]3CC[C@]12C)OC(=O)NCCN(C)C
• InChI: 1S/C32H56N2O2/c1-22(2)9-8-10-23(3)27-13-14-28-26-12-11-24-21-25(36-30(35)33-19-20-34(6)7)15-17-31(24,4)29(26)16-18-32(27,28)5/h11,22-23,25-29H,8-10,12-21H2,1-7H3,(H,33,35)/t23-,25?,26+,27-,28+,29+,31+,32-/m1/s1
• InChI key: HIHOWBSBBDRPDW-MTIZRNOUSA-N

Description

Application

• Role of interleukin-6 in antigen-specific mucosal immunoglobulin A induction by cationic liposomes.: This study investigates the use of cholesteryl N-(2-dimethylaminoethyl)carbamate in cationic liposomes for enhancing mucosal immunoglobulin A production, highlighting its potential in vaccine development (Tada et al., 2021).


• Nasal vaccination with pneumococcal surface protein A in combination with cationic liposomes consisting of DOTAP and DC-chol confers antigen-mediated protective immunity against Streptococcus pneumoniae infections in mice.: This research demonstrates the efficacy of cholesteryl N-(2-dimethylaminoethyl)carbamate in nasal vaccines, providing a promising strategy for respiratory infection prevention (Tada et al., 2018).

Biochem/physiol Actions

Cationic liposome, investigated in cancer gene therapy[1], as vaccine delivery system/adjuvant[2].

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Safety Information

• hcodes: H413
• Hazard Classifications: Aquatic Chronic 4
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable