The stability of this product in solution is not determined. However, similar product F3506 states that solutions of N-Formyl-Met-Leu-Phe can be stored, in aliquots, at -20°C for at least six months.
47729
N-Formyl-Met-Leu-Phe
≥99.0% (TLC), BioXtra
Synonym(s):
Chemotactic peptide, N-Formyl-L-methionyl-L-leucyl-L-phenylalanine, fMLF, fMLP (misnomer but widely used)
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 10 mg | Check Cart for Availability | CLP 190,000 |
About This Item
Empirical Formula (Hill Notation):
C21H31N3O5S
CAS Number:
Molecular Weight:
437.55
NACRES:
NA.26
PubChem Substance ID:
UNSPSC Code:
12352209
MDL number:
Beilstein/REAXYS Number:
2315783
Product Name
N-Formyl-Met-Leu-Phe, BioXtra, ≥99.0% (TLC)
product line
BioXtra
Quality Level
assay
≥99.0% (TLC)
form
powder
color
white
solubility
DMF: 50 mg/mL, clear, colorless
application(s)
cell analysis
storage temp.
2-8°C
SMILES string
CSCC[C@H](NC=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
InChI
1S/C21H31N3O5S/c1-14(2)11-17(23-19(26)16(22-13-25)9-10-30-3)20(27)24-18(21(28)29)12-15-7-5-4-6-8-15/h4-8,13-14,16-18H,9-12H2,1-3H3,(H,22,25)(H,23,26)(H,24,27)(H,28,29)/t16-,17-,18-/m0/s1
InChI key
PRQROPMIIGLWRP-BZSNNMDCSA-N
Gene Information
human ... FPR1(2357)
Application
1. 4th and 5th applications do not have access
2. 3rd application is not relevant
2. 3rd application is not relevant
Biochem/physiol Actions
N-Formyl-Met-Leu-Phe is a potent chemotactic peptide and formyl peptide receptor (FPR) agonist that induces a metabolic burst in macrophages accompanied by an increase in respiratory rate, secretion of lysosomal enzymes, and production of superoxide anion.
Potent chemotactic peptide. Induces a metabolic burst in macrophages accompanied by an increase in respiratory rate, secretion of lysosomal enzymes, and production of superoxide anion.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
1 of 1
This Item | |||
|---|---|---|---|
| form powder | form powder | form powder | form - |
| assay ≥99.0% (TLC) | assay ≥97% (HPLC) | assay ≥98% (TLC) | assay 98% |
| product line BioXtra | product line - | product line - | product line - |
| storage temp. 2-8°C | storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C |
| Quality Level 100 | Quality Level 100 | Quality Level 200 | Quality Level 200 |
| color white | color - | color white | color - |
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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C Dahlgren et al.
Blood, 95(5), 1810-1818 (2000-02-26)
A D-methionine-containing peptide, Trp-Lys-Tyr-Met-Val-D-Met-NH(2) (WKYMVm), featuring a unique receptor specificity was investigated with respect to its ability to activate neutrophil effector functions. The peptide was found to be more potent than the N-formylated peptide N-formyl-Met-Leu-Phe (fMLF) at inducing neutrophil chemotaxis
Karama Makni-Maalej et al.
Journal of immunology (Baltimore, Md. : 1950), 189(9), 4657-4665 (2012-09-25)
Superoxide anion production by the neutrophil NADPH oxidase plays a key role in host defense; however, excessive superoxide production is believed to participate to inflammatory reactions. Neutrophils express several TLR that recognize a variety of microbial motifs or agonists. The
Jing Wang et al.
Nature immunology, 14(1), 34-40 (2012-11-13)
Acute inflammatory responses are important in host defense, whereas dysregulated inflammation results in life-threatening complications. Here we found that paired immunoglobulin-like type 2 receptor alpha (PILRα), an inhibitory receptor containing immunoreceptor tyrosine-based inhibitory motifs (ITIMs), negatively regulated neutrophil infiltration during
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 47729-10MG-F | 04061832372921 |
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How long can this product be stored at -20 when reconstituted in DMSO?
1 answer-
Helpful?
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What is the solubility of the product 47729, N-Formyl-Met-Leu-Phe?
1 answer-
Product is soluble in water (partly), methanol, DMSO (4 mg/ml), ethanol (2 mg/ml), and DMF (Dimethylformamide) (50 mg/ml).
Helpful?
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Can this product be dissolved in DMSO?
1 answer-
Yes, this product can be solubilized in DMSO. The exact concentration at which it may be solubilized is not determined. However, several sources state that it is soluble in DMSO at 30 mg/mL.
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