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Galangin

Name: Galangin
Brand: SIGMA

autophagy inducing flavonoid

Synonym(s):

3,5,7-Trihydroxyflavone, Norizalpinin

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About This Item

Empirical Formula (Hill Notation):

C₁₅H₁₀O₅

CAS Number:

548-83-4

Molecular Weight:

270.24

UNSPSC Code:

41116107

NACRES:

NA.79

PubChem Substance ID:

57648294

EC Number:

208-960-4

Beilstein/REAXYS Number:

272179

MDL number:

MFCD00006833

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Properties

Quality Segment

100

assay

≥95% (HPLC)

form

powder

color

yellow

mp

214-215 °C (lit.)

SMILES string

Oc1cc(O)c2C(=O)C(O)=C(Oc2c1)c3ccccc3

InChI

1S/C15H10O5/c16-9-6-10(17)12-11(7-9)20-15(14(19)13(12)18)8-4-2-1-3-5-8/h1-7,16-17,19H

InChI key

VCCRNZQBSJXYJD-UHFFFAOYSA-N

Gene Information

human ... ADORA2A(135), ADORA3(140), CYP1A2(1544)
rat ... Adora1(29290), Adora2a(25369)

Description

General description

Galangin is a flavonoid isolated from members of the Zingiberaceae family, which are mainly used for herbal medicines.[1]

Application

Galangin has been used:

as a test drug to test its ameliorative effect in a rodent model of cisplatin-induced nephrotoxicity[1]
to test its effect on the differentiation of 3T3-L1 preadipocyte cells into adipocytes[2]
as an internal standard in nuclear magnetic resonance spectroscopy and mass spectroscopy

Biochem/physiol Actions

Galangin exhibits antioxidant, anti-apoptotic, anti-inflammatory[1] and anti-obesity properties.[3] In addition, it also possesses anti-genotoxic activity against environmental and dietary carcinogens. Galangin inhibits cancer growth by hindering cancer cell proliferation, induction of apoptosis and autophagy and inhibition of metastasis. Galangin also has an ability to inhibit CYP1A1 (Cytochrome P450, family 1, member A1) activity.

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This Item	92342	69545	10798
Sigma-Aldrich 282200 Galangin	Supelco 92342 Galangin	Supelco 69545 Kaempferide	Sigma-Aldrich 10798 Apigenin
assay ≥95% (HPLC)	assay ≥97.0% (HPLC)	assay ≥99.0% (HPLC)	assay ≥95.0% (HPLC)
form powder	form powder or crystals	form -	form -
color yellow	color faint yellow to dark yellow	color -	color -
mp 214-215 °C (lit.)	mp 214-215 °C (lit.)	mp -	mp >300 °C (lit.)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
Gene Information human ... ADORA2A(135), ADORA3(140), CYP1A2(1544) rat ... Adora1(29290), Adora2a(25369)	Gene Information -	Gene Information -	Gene Information human ... ADORA3(140), CDC2(983), CDK5(1020), CDK6(1021), CYP1A2(1544), ESR1(2099), ESR2(2100), GSK3A(2931) mouse ... Hexa(15211) rat ... Adora1(29290), Adora2a(25369), Il4(287287), Tnf(24835)

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pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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