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T14001

Sigma-Aldrich

3,4,5,6-Tetrahydrophthalic anhydride

95%

Synonym(s):

Cyclohexene-1,2-dicarboxylic anhydride

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About This Item

Empirical Formula (Hill Notation):
C8H8O3
CAS Number:
2426-02-0
Molecular Weight:
152.15
Beilstein:
136335
EC Number:
219-374-3
MDL number:
MFCD00005917
UNSPSC Code:
12162002
PubChem Substance ID:
24899964
NACRES:
NA.23

Quality Level

100

Assay

95%

mp

69-73 °C (lit.)

SMILES string

O=C1OC(=O)C2=C1CCCC2

InChI

1S/C8H8O3/c9-7-5-3-1-2-4-6(5)8(10)11-7/h1-4H2

InChI key

HMMBJOWWRLZEMI-UHFFFAOYSA-N

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Pictograms

Health hazardCorrosion
GHS08,GHS05

Signal Word

Danger

Hazard Statements

H317,H318,H334,H412

Hazard Classifications

Aquatic Chronic 3 - Eye Dam. 1 - Resp. Sens. 1 - Skin Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A Ikai et al.
The Journal of biological chemistry, 265(14), 8280-8284 (1990-05-15)
As a model for the molecular structure of proteins belonging to the alpha 2-macroglobulin family, ovomacroglobulin of reptilian origin was studied by electron microscopy in the original tetrameric form as well as in the dissociated forms into half- and quarter
J B Swaney
Journal of lipid research, 24(3), 245-252 (1983-03-01)
Trypsin digestion of human high density lipoprotein (d 1.125-1.21 g/ml) on which the lysine residues have been masked with the reversible blocking group, 2,3,4,5-tetrahydrophthallic anhydride (THPA), was found to result in the fragmentation of the apoA-I component, but not the
Subat Turdi et al.
Toxicology letters, 178(3), 197-201 (2008-05-10)
Doxorubicin is an effective anthracycline used for cancer therapy. However, the clinical application of doxorubicin has been largely limited by its irreversible cardiotoxicity, which is mainly induced by the primary amine group. In this study, we structurally modified doxorubicin by
[Data providing a basis for the MPEL of tetrahydrophthalic anhydride, tetrahydrophthalamide and hydroxymethyltetrahydrophthalimide in the air of the work environment].
A I Gurova et al.
Gigiena truda i professional'nye zabolevaniia, (12)(12), 37-38 (1985-12-01)
L I O'Connell et al.
Archives of biochemistry and biophysics, 263(2), 315-322 (1988-06-01)
Modification of glutamate dehydrogenase with 3,4,5,6-tetrahydrophthalic anhydride at pH 8.0 results in the progressive loss of enzymatic activity and a concomitant increase in the negative charge of the protein. Although the rate of inactivation at room temperature is too rapid

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