Skip to Content
Merck
All Photos(1)

Documents

SML1088

Sigma-Aldrich

SRPIN340

≥98% (HPLC)

Synonym(s):

(SRPIN)340, N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C18H18F3N3O
CAS Number:
218156-96-8
Molecular Weight:
349.35
MDL number:
MFCD00116244
UNSPSC Code:
51111800
PubChem Substance ID:
329825465
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(C1=CC=NC=C1)NC2=C(N3CCCCC3)C=CC(C(F)(F)F)=C2

InChI

1S/C18H18F3N3O/c19-18(20,21)14-4-5-16(24-10-2-1-3-11-24)15(12-14)23-17(25)13-6-8-22-9-7-13/h4-9,12H,1-3,10-11H2,(H,23,25)

InChI key

DWFGGOFPIISJIT-UHFFFAOYSA-N

Application

SRPIN340 has been used as a serine-arginine protein kinase (SRPK) inhibitor to identify if SRPK can phosphorylate the E3 ubiquitin ligase RNF12 ser/arg (SR)-motifs in vivo.

Biochem/physiol Actions

SRPIN340 is a cell-permeable, specific and potent inhibitor of Serine-Arginine-Rich Protein Kinase (SRPK) that down-regulates SRp75 and inhibits expression of Sindbis, hepatitis C virus (HCV), HIV, and cytomegalovirus viruses. SRPIN340 appears to be most effective for inhibiting acutely replicating viruses. SRPIN340 suppresses Vegf expression and attenuated choroidal neovascularization (CNV) formation in mice model.
SRPIN340 is an isonicotinamide compound. It protects cardiomyocytes against hydrogen peroxide (H2O2) induced oxidative damage by serine-arginine protein kinase 1/2 (SRPK1/2) inhibition-mediated protein kinase B (AKT) activation.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Jian Huang et al.
Biochemical and biophysical research communications, 510(1), 97-103 (2019-01-22)
SRPIN340, a selective serine-arginine protein kinase 1/2 (SRPK1/2) inhibitor, has been shown to have antiviral and anti-angiogenesis effects. However, its role in the heart is unknown. The present study explored the role of SRPIN340 in myocardial protection and the related
Zhenyu Dong et al.
Molecular vision, 19, 536-543 (2013-04-06)
To investigate the applicability of serine/arginine-rich protein kinase (SRPK)-specific inhibitor, SRPIN340, for attenuation of choroidal neovascularization (CNV) formation using a mouse model. Laser photocoagulation was performed to induce CNV in C57BL/6J mice, followed by intravitreal injection of SRPIN340 or vehicle.
Hugues de Boussac et al.
Haematologica, 105(3), 784-795 (2019-07-11)
Multiple myeloma (MM) account for approximately 10% of hematological malignancies and is the second most common hematological disorder. Kinases inhibitors are widely used and their efficiency for the treatment of cancers has been demonstrated. Here, in order to identify kinases
Alzahraa A M Fergany et al.
Recent patents on anti-cancer drug discovery, 15(4), 293-305 (2020-09-10)
RNA splicing, a fundamental step in gene expression, is aimed at intron removal and ordering of exons to form the protein's reading frame. This review is focused on the role of RNA splicing in cancer biology; the splicing abnormalities that
Gabriela Alves Moreira et al.
Toxicology and applied pharmacology, 356, 214-223 (2018-08-24)
The Serine/arginine-rich protein kinases (SRPK) are involved in pre-mRNA splicing control through the phosphorylation of the SR protein family of splicing factors. Over the last years, several studies have shown the relevance of SRPK for human cancers and their potential
View All Related Papers

Articles

Bioactive Molecules for Immunology Research

Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.

Bioactive Molecules for Immunology Research

Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.

Bioactive Molecules for Immunology Research

Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.

Bioactive Molecules for Immunology Research

Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service