SAB4501060

Anti-GAB1 antibody produced in rabbit

affinity isolated antibody

• Synonym(s): GRB2-associated binder 1, GRB2-associated-binding protein 1, growth factor receptor bound protein 2-associated protein 1
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 76 kDa
• species reactivity: mouse, rat, human
• concentration: ~1 mg/mL
• technique(s): immunohistochemistry: suitable; western blot: suitable
• NCBI accession no.: Q13480
• UniProt accession no.: Q13480
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... GAB1(2549)

Description

General description

Anti-GAB1 Antibody detects endogenous levels of total GAB1 protein.

The GRB2 associated binding protein 1 (GAB1) protein is encoded by the gene mapped to human chromosome 4q31.21. The encoded protein belongs to the Grb2-associated binding protein family. GAB1 protein structure contains pleckstrin homology domain and tyrosine residues. Anti-GAB1 Antibody detects endogenous levels of total GAB1 protein.

Immunogen

The antiserum was produced against synthesized peptide derived from human GAB1.

Immunogen Range: 644-674

Application

Anti-GAB1 antibody produced in rabbit has been used in proximity ligation assay (1:100) and western blotting.

Biochem/physiol Actions

GRB2 associated binding protein 1 (GAB1) acts as a scaffold protein for protein-protein interaction. It regulates growth factor receptors and enhances signal transduction of multiple intracellular signaling pathways, such as phosphatidylinositol 3-kinase and protein kinase B (PKB/AKT)/ mammalian target of rapamycin (mTOR) signaling pathways. Upregulated expression of GAB1 contributes to the progression of various types of cancer including human oral squamous cell carcinoma (OSCC), breast cancer, colorectal cancer, hepatocellular carcinoma, and ovarian cancer. Therefore, knockdown of the GAB1 gene can be considered as a potential therapeutic strategy for treating breast cancer and OSCC.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: nwg
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable