N8133
Nerve Growth Factor from Vipera lebetina venom
NGF, lyophilized powder, suitable for cell culture
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About This Item
Recommended Products
biological source
Vipera Lebetina
Quality Level
form
lyophilized powder
potency
0.2-20 μg/mL ED50/EC50
quality
endotoxin tested
mol wt
protein 32.5 kDa
packaging
pkg of 0.1 mg
technique(s)
cell culture | mammalian: suitable
impurities
<10 EU/vial
color
white to off-white
UniProt accession no.
storage temp.
−20°C
Physical form
Lyophilized from a 0.2 μm filtered solution in sodium acetate buffer.
Preparation Note
Isolated from the snake venom of V. lebetina.
Analysis Note
The biological activity of Nerve Growth Factor (NGF) from Vipera lebetina venom is measured in a cell proliferation assay using PC-12 cells.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Yu-Jung Chang et al.
Biochimica et biophysica acta, 1830(8), 4130-4136 (2013-04-16)
Neurotrophins are important regulators for neural development and regeneration. Nerve growth factor (NGF) therapy has been tested in various models of neural injury and degeneration. However, whether NGF can reach target tissues and maintain effective concentration for a certain period
Federica De Angelis et al.
Journal of cellular physiology, 229(6), 783-790 (2013-10-30)
The peripheral application of the M2 cholinergic agonist arecaidine on sensory nerve endings shows anti-nociceptive properties. In this work, we analyze in vitro, the mechanisms downstream M2 receptor activation causing the analgesic effects, and in vivo the effects produced by
Geraldine Longo et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(24), 10066-10074 (2013-06-14)
Although chronic pain is the most common symptom of arthritis, relatively little is known about the mechanisms driving it. Recently, a sprouting of autonomic sympathetic fibers into the upper dermis of the skin, an area that is normally devoid of
Gloria Roberti et al.
Journal of cellular physiology, 229(9), 1130-1133 (2014-02-07)
Nerve growth factor (NGF) is an endogenous neurotrophin involved in the development, maintenance and regeneration of mammalian sympathetic and sensory neurons. Additionally, NGF is known to have trophic and differentiating activity on several populations of cholinergic neurons of the central
Rachel T Uren et al.
Journal of neurochemistry, 129(4), 614-627 (2014-02-04)
Suppressor of cytokine signaling-2 (SOCS2) is a regulator of intracellular responses to growth factors and cytokines. Cultured dorsal root ganglia neurons from neonatal mice with increased or decreased SOCS2 expression were examined for altered responsiveness to nerve growth factor (NGF).
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