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Key Documents

N7032

Sigma-Aldrich

NFAT Inhibitor

>96% (HPLC), solid

Synonym(s):

VIVIT

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About This Item

Empirical Formula (Hill Notation):
C75H118N20O22S
CAS Number:
249537-73-3
Molecular Weight:
1683.93
MDL number:
MFCD02683959
UNSPSC Code:
12352202
NACRES:
NA.26

Quality Level

300

Assay

>96% (HPLC)

form

solid

storage temp.

−20°C

InChI

1S/C75H118N20O22S/c1-12-39(7)59(90-70(111)57(37(3)4)88-68(109)52-19-16-27-95(52)74(115)49(30-44-32-78-36-82-44)87-67(108)51-18-15-26-94(51)53(97)33-79-62(103)41(9)83-63(104)45(76)24-28-118-11)72(113)89-58(38(5)6)71(112)91-60(40(8)13-2)73(114)92-61(42(10)96)69(110)80-34-54(98)93-25-14-17-50(93)66(107)86-48(29-43-31-77-35-81-43)65(106)84-46(20-22-55(99)100)64(105)85-47(75(116)117)21-23-56(101)102/h31-32,35-42,45-52,57-61,96H,12-30,33-34,76H2,1-11H3,(H,77,81)(H,78,82)(H,79,103)(H,80,110)(H,83,104)(H,84,106)(H,85,105)(H,86,107)(H,87,108)(H,88,109)(H,89,113)(H,90,111)(H,91,112)(H,92,114)(H,99,100)(H,101,102)(H,116,117)/t39-,40-,41-,42+,45-,46-,47-,48-,49-,50-,51-,52-,57-,58-,59-,60-,61-/m0/s1

InChI key

QPMHUXBSHGAVGD-MCDIZDEASA-N

Gene Information

human ... NFATC1(4772) , NFATC2(4773)
mouse ... Nfatc1(18018) , Nfatc2(18019)

Amino Acid Sequence

Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu

Application

NFAT Inhibitor, VIVIT has been used to study the signaling pathways involved in controlling inhibitory molecules and subsequent onset of T-cell impairment.
NFAT inhibitor has been as an inhibitor of nuclear factor of activated T cells.

Biochem/physiol Actions

High-affinity calcineurin-binding peptide that inhibits NFAT (Nuclear Factor of Activated T cells) activation and NFAT-dependent expression of endogenous cytokine genes in T cells.
Nuclear factor of activated T cells (NFAT) participates in the activity and growth of immune and non-immune cells.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Carmela Gallo et al.
Cellular and molecular life sciences : CMLS, 79(7), 369-369 (2022-06-21)
The immune response arises from a fine balance of mechanisms that provide for surveillance, tolerance, and elimination of dangers. Sulfavant A (SULF A) is a sulfolipid with a promising adjuvant activity. Here we studied the mechanism of action of SULF
Adolf E Schindler
International journal of women's health, 3, 175-184 (2011-07-28)
Endometriosis is a chronic disease primarily affecting women of childbearing age, in which endometriotic lesions form outside the uterus, typically leading to painful symptoms, fatigue, and infertility. The symptoms of endometriosis may cause significant impairment in quality of life and
p38 Mitogen-Activated Protein Kinase/Signal Transducer and Activator of Transcription-3 Pathway Signaling Regulates Expression of Inhibitory Molecules in T Cells Activated by HIV-1?Exposed Dendritic Cells
Karlhans Fu Che
Molecular Medicine (2012)
Karlhans Fru Che et al.
Molecular medicine (Cambridge, Mass.), 18, 1169-1182 (2012-07-11)
Human immunodeficiency virus type 1 (HIV-1) infection enhances the expression of inhibitory molecules on T cells, leading to T-cell impairment. The signaling pathways underlying the regulation of inhibitory molecules and subsequent onset of T-cell impairment remain elusive. We showed that

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