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Merck

M7317

Sigma-Aldrich

Monoclonal Anti-MDR3 P-Glycoprotein antibody produced in mouse

250 μg/mL, clone P3II-26, tissue culture supernatant

Synonym(s):

Anti-ABC21, Anti-GBD1, Anti-ICP3, Anti-MDR2, Anti-MDR2/3, Anti-MDR3, Anti-PFIC-3, Anti-PGY3

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About This Item

MDL number:
UNSPSC Code:
12352203
NACRES:
NA.41

Pricing and availability is not currently available.

biological source

mouse

Quality Level

conjugate

unconjugated

antibody form

tissue culture supernatant

antibody product type

primary antibodies

clone

P3II-26, monoclonal

species reactivity

human

concentration

250 μg/mL

technique(s)

immunocytochemistry: 1:20-1:50 using acetone-fixed cytospin preparations
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable (not suitable for human tissues)
immunohistochemistry (frozen sections): 1:20 using acetone-fixed sections
western blot: suitable

isotype

IgG2b

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MABC1102SAB1300211SAB1300453
antibody form

IgG fraction of antiserum

antibody form

purified immunoglobulin

antibody form

IgG fraction of antiserum

antibody form

IgG fraction of antiserum

biological source

rabbit

biological source

mouse

biological source

rabbit

biological source

rabbit

shipped in

dry ice

shipped in

-

shipped in

dry ice

shipped in

dry ice

UniProt accession no.

Q9UBU2

UniProt accession no.

Q9UBU2

UniProt accession no.

Q9UBT3

UniProt accession no.

Q96PY6

clone

polyclonal

clone

5F8, monoclonal

clone

polyclonal

clone

polyclonal

General description

Multidrug resistance protein 3 (MDR3) is also known as ATP binding cassette subfamily B member 4. It is expressed in hepatocytes and made up of 1279 amino acids. The gene encoding it is localized on human chromosome 7q21.12 and consists of 27 exons.

Specificity

Reacts with an internal epitope of MDR3. Does not cross-react with human MDR1 P-gp.

Immunogen

MDR3 P-gp (amino acids 629-692) GST fusion protein.

Biochem/physiol Actions

Multidrug resistance protein 3 (MDR3) acts as an ATP-dependent exporter and transfers phospholipids, particularly phosphatidylcholine (PC), into bile. Dysfunctioning of MDR3 leads to excess of bile salts in primary bile and further leads to liver diseases.

Physical form

Supplied in serum-free medium containing 0.7% bovine serum albumin and 0.1% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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Hao-Zhe Sun et al.
World journal of gastroenterology, 21(2), 699-703 (2015-01-17)
Genotyping is conclusive for the diagnosis of progressive familial intrahepatic cholestasis type 3 (PFIC3). Here we report a Chinese patient of PFIC3 with compound mutations in the ABCB4 gene. Liver biopsy was performed on a 17-year-old male patient with intrahepatic
Marianne Kluth et al.
The Journal of biological chemistry, 290(8), 4896-4907 (2014-12-24)
The human multidrug resistance protein 3 (MDR3/ABCB4) belongs to the ubiquitous family of ATP-binding cassette (ABC) transporters and is located in the canalicular membrane of hepatocytes. There it flops the phospholipids of the phosphatidylcholine (PC) family from the inner to
Steffen Kiehl et al.
Scientific reports, 4, 6899-6899 (2014-11-05)
Epigenetic silencing through promoter hypermethylation is an important hallmark for the inactivation of tumor-related genes in carcinogenesis. Here we identified the ATP-binding cassette sub-family B member 4 (ABCB4) as a novel epigenetically silenced target gene. We investigated the epigenetic regulation
Yu Zhao et al.
Journal of lipid research, 56(3), 644-652 (2015-01-21)
ABCB4, which is specifically expressed on the canalicular membrane of hepatocytes, exports phosphatidylcholine (PC) into bile. Because SM depletion increases cellular PC content and stimulates PC and cholesterol efflux by ABCA1, a key transporter involved in generation of HDL, we

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