I4032
Interleukin-21 from mouse
≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
Synonym(s):
IL-21
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About This Item
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biological source
mouse
recombinant
expressed in E. coli
Assay
≥97% (SDS-PAGE)
form
lyophilized powder
potency
40-120 ng/mL ED50
mol wt
predicted mol wt ~14.4 kDa
packaging
pkg of 10 μg
storage condition
avoid repeated freeze/thaw cycles
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
mouse ... Il21(60505)
Biochem/physiol Actions
IL-21 (interleukin-21) belongs to the IL-2 cytokine family. It is secreted by CD4+ T, natural killer (NK) and Th17 cells. IL-21 associates with IL-21 receptor and participates in B-cell proliferation, differentiation as well as apoptosis. It also promotes the cytotoxic activity of CD8+ T cells and natural killer cells.IL-21 plays a crucial role in the differentiation of follicular helper T cells. It also exhibits antitumor activity. It is also involved in the activation of JAK-STAT (Janus kinase - signal transducer and activator of transcription), PI3K (phosphatidylinositol 3-kinase) and MAPK (mitogen activated protein kinase) pathways.
IL-21 and its receptor have important roles in T and B cell proliferation and natural killer cell maturation. Human and mouse IL-21 share 57% amino acid identity.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 0.5 mg bovine serum albumin.
Analysis Note
The biological activity is measured by its ability to induce proliferation of human N1186 T cells.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Antigen-specific monoclonal antibodies isolated from B cells expressing constitutively active STAT5.
Ferenc A Scheeren et al.
PloS one, 6(4), e17189-e17189 (2011-04-29)
Fully human monoclonal antibodies directed against specific pathogens have a high therapeutic potential, but are difficult to generate. Memory B cells were immortalized by expressing an inducible active mutant of the transcription factor Signal Transducer and Activator of Transcription 5
Mark J Kwakkenbos et al.
Nature medicine, 16(1), 123-128 (2009-12-22)
The B cell lymphoma-6 (Bcl-6) and Bcl-xL proteins are expressed in germinal center B cells and enable them to endure the proliferative and mutagenic environment of the germinal center. By introducing these genes into peripheral blood memory B cells and
Pablo D Becker et al.
PloS one, 5(10) (2010-10-20)
Passive transfer of antibodies not only provides immediate short-term protection against disease, but also can be exploited as a therapeutic tool. However, the 'humanization' of murine monoclonal antibodies (mAbs) is a time-consuming and expensive process that has the inherent drawback
Shruti Bhatt et al.
Blood, 126(13), 1555-1564 (2015-07-22)
Mantle cell lymphoma (MCL) is a distinct subtype of non-Hodgkin lymphoma characterized by overexpression of cyclin D1 in 95% of patients. MCL patients experience frequent relapses resulting in median survival of 3 to 5 years, requiring more efficient therapeutic regimens.
S Lajoie et al.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 44(7), 976-985 (2014-05-09)
Interleukin-21 (IL-21) has been implicated in the development of Th2-mediated immune responses; however, the exact role it plays in allergic diseases is not well understood. To elucidate the contribution of IL-21 receptor signalling to Th2-dependent immune responses in the lung.
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