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H4539

Sigma-Aldrich

Anti-Histone Deacetylase 11 (HDAC11) antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-HD11, Anti-HDAC11

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About This Item

MDL number:
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~39 kDa

species reactivity

mouse, human

concentration

~1 mg/mL

technique(s)

western blot (chemiluminescent): 0.5-1 μg/mL using extracts of mouse brain
western blot (chemiluminescent): 4-6 μg/mL using nuclear extracts of HeLa cells.

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

Related Categories

General description

Anti-Histone Deacetylase 11 (HDAC11) is developed in rabbit using a synthetic peptide corresponding to amino acid residues 2-16 of human HDAC11 with an N-terminal added cysteine, conjugated to KLH, as immunogen. Histone deacetylase 11 (HDAC11) belongs to the class IV member of the histone deacetylase (HDAC) family. It is mainly expressed in brain, heart, skeletal muscle, kidney, testis, immune cells and cancer cells. HDAC11 has a molecular weight of 39 kDa. The protein consists of one catalytic domain and is found in a complex with HDAC6. This gene is mapped to human chromosome 3p25.

Immunogen

synthetic peptide corresponding to amino acids 2-16 of human HDAC11 with an N-terminal added cysteine, conjugated to KLH. The corresponding sequence differs by three amino acids in both rat and mouse HDAC11.

Application

Anti-Histone Deacetylase 11 (HDAC11) antibody produced in rabbit has been used in chromatin immunoprecipitation (ChIP) and western blotting analysis.

Biochem/physiol Actions

Histone acetylation is a dynamic process whose levels are determined by the net activities of HATs and the competing enzymes histone deacetylases (HDACs). Histone Deacetylase 11 (HDAC11) modulates immune activation and tumorigenesis. It negatively controls the synthesis of interleukin-10 (IL-10) in antigen-presenting cells (APCs). It also modulates type I interferon (IFN) signalling.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Cloning and Functional Characterization of HDAC11, a Novel Member of the Human Histone Deacetylase Family
Gao L, et al.
The Journal of Biological Chemistry, 277(28), 25748-25755 (2002)
HDAC11 regulates type I interferon signaling through defatty-acylation of SHMT2
Cao J, et al.
Proceedings of the National Academy of Sciences of the USA, 116(12), 5487-5487 (2019)
The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance
Villagra A, et al.
Nature Immunology, 10(1), 92-100 (2008)
Histone deacetylase inhibitor LAQ824 augments inflammatory responses in macrophages through transcriptional regulation of IL-10
Wang H, et al.
Journal of Immunology, 186(7), 3986-3996 (2011)
Inhibition of histone deacetylases 1 and 6 enhances cytarabine-induced apoptosis in pediatric acute myeloid leukemia cells
Xu X, et al.
Testing, 6(2), e17138-e17138 (2011)

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