Skip to Content
Merck
All Photos(1)

Documents

227M-9

Sigma-Aldrich

BCL6 (GI191E/A8) Mouse Monoclonal Antibody

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

GI191E/A8, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (227M-94)
vial of 0.5 mL concentrate (227M-95)
bottle of 1.0 mL predilute (227M-97)
vial of 1.0 mL concentrate (227M-96)
bottle of 7.0 mL predilute (227M-98)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

control

tonsil

shipped in

wet ice

storage temp.

2-8°C

visualization

nuclear

Gene Information

human ... BCL6(604)

General description

BCL6 is a transcriptional regulator gene that codes for a 706-amino-acid nuclear zinc finger protein. In normal tissue, anti-BCL6 antibody shows strong nuclear staining in a subset of B-lymphocytes, mostly located in germinal centers (GC). BCL6 expression is usually present in follicular lymphomas, diffuse large B-cell lymphomas, and Burkitt lymphomas.

Quality


IVD
IVD
IVD
RUO

Linkage

BCL6 Positive Control Slides, Product No. 227S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

Not finding the right product?  

Try our Product Selector Tool.

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

A Carbone et al.
Blood, 90(6), 2445-2450 (1997-10-06)
The expression pattern of the BCL-6 transcription factor has been assessed in normal and neoplastic B-cell populations and in Hodgkin's disease. However, little is known about BCL-6 expression and its biological significance in T-cell neoplasms. In this study, a series
A Carbone et al.
Blood, 91(3), 747-755 (1998-02-03)
This study was aimed at defining the histogenesis of the pathologic spectrum of acquired immunodeficiency syndrome-related non-Hodgkin's lymphomas (AIDS-NHL), including AIDS-related small noncleaved cell lymphoma (AIDS-SNCCL), AIDS-related large noncleaved cell lymphoma (AIDS-LNCCL), AIDS-related large cell immunoblastic lymphoma plasmacytoid (AIDS-IBLP), and
Antonino Carbone et al.
Human pathology, 41(5), 621-631 (2010-04-20)
Published in September 2008, the updated World Health Organization Classification of Tumors of Hematopoietic and Lymphoid Tissues introduces provisional borderline categories for lymphoma cases that demonstrate overlapping clinical, morphological, and/or immunophenotypic features between well-established entities. These overlapping features pose real
José-Francisco García et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 54(1), 31-38 (2005-07-28)
Genetic immunization can be combined with hybridoma technology to generate high-affinity monoclonal antibodies (MAbs). A new anti-BCL-6 MAb (GI191E/A8) was produced by cloning full-length BCL-6 cDNA into a eukaryotic vector and delivering this into mouse epidermis using a helium gene
B Falini et al.
Annals of oncology : official journal of the European Society for Medical Oncology, 8 Suppl 2, 101-104 (1997-01-01)
The human bcl-6 gene, which is rearranged in about 30% of diffuse large B-cell lymphomas (DLCL-B), encodes for a Kruppel-type zinc finger protein of 706 amino acids. In order to investigate the expression of the bcl-6 gene at the protein
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service