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199508

Sigma-Aldrich

Acridine Yellow G

Dye content 90 %

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About This Item

Empirical Formula (Hill Notation):
C15H15N3 · HCl
CAS Number:
Molecular Weight:
273.76
Colour Index Number:
46025
EC Number:
MDL number:
UNSPSC Code:
12171500
PubChem Substance ID:
NACRES:
NA.47

form

crystalline powder

Quality Level

composition

Dye content, 90%

solubility

water: 1 mg/mL, clear, yellow to orange

λmax

442 nm

ε (extinction coefficient)

44000 at 262-268 nm

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

Cl[H].Cc1cc2cc3cc(C)c(N)cc3nc2cc1N

InChI

1S/C15H15N3.ClH/c1-8-3-10-5-11-4-9(2)13(17)7-15(11)18-14(10)6-12(8)16;/h3-7H,16-17H2,1-2H3;1H

InChI key

BGLGAKMTYHWWKW-UHFFFAOYSA-N

Biochem/physiol Actions

Acridine Yellow G (AYG) is an organic dye with photophysical properties. It is widely used in optics, medicine and photovoltaic cells. AYG has been used as a solar photocatalyst to increase biodegradability and remove ferulic acid, a target pollutant from wastewater. It retards the growth of glioblastoma via dual inhibition of epidermal growth factor receptor and protein kinase c kinases.

Pictograms

Health hazardExclamation mark

Signal Word

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Qi Qi et al.
The Journal of biological chemistry, 287(9), 6113-6127 (2012-01-05)
Amplification of the epidermal growth factor receptor (EGFR), frequently expressed as a constitutively active deletion mutant (EGFRvIII), occurs commonly in glioblastoma multiformes (GBM). However, blockade of EGFR is therapeutically disappointing for gliomas with PTEN deletion. To search for small molecules
T Pérez-Ruíz et al.
Analytical and bioanalytical chemistry, 375(5), 661-665 (2003-03-15)
A flow-injection configuration for the determination of formaldehyde is proposed. The method is based on the enhancing effect of formaldehyde on the oxidation of acridine yellow by bromate in acidic medium. The proposed procedure is simple, inexpensive, sensitive and suitable
M Teuber et al.
Biochimica et biophysica acta, 1506(1), 31-46 (2001-06-22)
Fluorescent DeltapH and DeltaPsi indicators have been screened for the non-invasive monitoring of bioenergetic processes in whole cells of the cyanobacterium Synechocystis sp. PCC 6803. Acridine yellow and Acridine orange proved to be the best DeltapH indicators for the investigation
G J Tangelder et al.
The American journal of physiology, 268(2 Pt 2), H909-H915 (1995-02-01)
A method is presented to assess in vivo in transparent tissues the leukocyte subtypes that roll in microvessels. In nine rabbits anesthetized with ketamine-xylazine, leukocyte nuclei were stained in situ with acridine yellow (3 mg/kg i.v. for 5 min). Intravital
Brotati Chakraborty et al.
The journal of physical chemistry. A, 114(51), 13313-13325 (2010-12-04)
Conventional spectroscopic tools such as absorption, fluorescence, and circular dichroism spectroscopy used in the study of photoinduced drug-protein interactions can yield useful information about ground-state and excited-state phenomena. However, photoinduced electron transfer (PET) may be a possible phenomenon in the

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