Carboxylate form of Lovastatin (Cat. No. 438185) that is active in whole cells and cell-free assays.
Carboxylate form of Lovastatin (Cat. No. 438185) that is active in whole cells and cell-free assays. Lovastatin is reported to be an anti-hypercholesterolemic agent that acts as an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and blocks a series of biological events including activation of p21ras by insulin in 3T3-L1 fibroblasts and 3T3-L1 adipocytes, farnesylation of p21ras, which decreases the pool of intracellular Ras available for subsequent activation by growth factors (including insulin), and N-ras-induced neuronal differentiation. Causes cell cycle arrest in the late G1 phase. Shown to inhibit the stimulation of MAP kinase by insulin in HIRcB cells and block the transcription of the type-I SCR gene in THP-1-derived macrophages. Also blocks PDGF receptor tyrosine phosphorylation and MAP kinase activation by PDGF.
Biochem/physiol Actions
Cell permeable: yes
Primary Target 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Warning
Toxicity: Carcinogenic / Teratogenic (D)
Reconstitution
Following reconstitution, aliquot, flush with an inert gas, and freeze (-20°C). Stock solutions in high quality ethanol are stable for up to 1 month at -20°C.
Other Notes
Rao, S., et al. 1999. Proc. Natl. Acad. Sci. USA96, 7197. Carel, K., et al. 1996. J. Biol. Chem.271, 30625. McGuire, T.F., et al. 1996. J. Biol. Chem.271, 27402. Umetani, N., et al. 1996. Biochim. Biophys. Acta1303, 199. Xu, X.Q., et al. 1996. Arch. Biochem. Biophys.326, 233. Reusch, J.E.-B., et al. 1995. J. Biol. Chem.270, 2036.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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