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268542

Sigma-Aldrich

Hydroxypropyl methacrylate

Mixture of hydroxypropyl and hydroxyisopropyl methacrylates, 97%, contains 180-220 ppm monomethyl ether hydroquinone as inhibitor

Synonym(s):

HPMA

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About This Item

CAS Number:
27813-02-1
Beilstein:
1752228
UNSPSC Code:
12162002
PubChem Substance ID:
24856280
NACRES:
NA.23

vapor density

>1 (vs air)

vapor pressure

0.05 mmHg ( 20 °C)

Assay

97%

form

liquid

contains

180-220 ppm monomethyl ether hydroquinone as inhibitor

refractive index

n20/D 1.447 (lit.)

bp

57 °C/0.5 mmHg (lit.)

density

1.066 g/mL at 25 °C (lit.)

storage temp.

2-8°C

SMILES string

CC(=C)C(=O)OCCCO

InChI

1S/C7H12O3/c1-5(2)7(9)10-6(3)4-8/h6,8H,1,4H2,2-3H3

InChI key

ZMARGGQEAJXRFP-UHFFFAOYSA-N

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Application


  • Synthesis of poly hydroxypropyl methacrylate cryogel incorporated with Zn/Ce substituted hydroxyapatite nanoparticles for rejuvenation of femoral fracture: This study explores the synthesis of a cryogel incorporating hydroxypropyl methacrylate and Zn/Ce substituted hydroxyapatite nanoparticles, aimed at bone fracture healing (H Zhou, H Jiao, J Xu, Y Liu, S Wei, 2019).

  • Poly(Hydroxypropyl methacrylate-co-glycidyl methacrylate): Facile synthesis of well-defined hydrophobic gels containing hydroxy-functional methacrylates: This article presents the synthesis of hydrophobic gels using hydroxypropyl methacrylate and glycidyl methacrylate, useful in various material applications (N Orakdogen, B Sanay, 2017).

  • Initiated chemical vapor deposition of poly(Hydroxypropyl methacrylate) thin films: The study covers the chemical vapor deposition process for creating thin films of poly(hydroxypropyl methacrylate) on membranes, enhancing their functional properties (E Sevgili, M Karaman, 2019).

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Danger

Hazard Classifications

Carc. 1B - Eye Irrit. 2 - Muta. 1B - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

203.0 °F - closed cup

Flash Point(C)

95 °C - closed cup

Certificates of Analysis (COA)

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Qingyu Xiang et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 80(2), 379-386 (2011-11-22)
In several groups of malignant tumors including head and neck tumors, a protein named Hsp47/CBP2 leaked from the cell was expressed on the tumor cell surface. Several synthetic peptides have been identified as effective ligands for binding to Hsp47/CBP2. This
Annette Kelsch et al.
Biomacromolecules, 13(12), 4179-4187 (2012-11-28)
In this work we describe the application of amphiphilic N-(2-hydroxypropyl)methacrylamide (HPMA)-based copolymers as polymeric surfactants in miniemulsion techniques. HPMA-based copolymers with different ratios of HPMA (hydrophilic) to laurylmethacrylate (LMA; hydrophobic) units were synthesized by RAFT polymerization and postpolymerization modification. The
Russell N Johnson et al.
Biomacromolecules, 13(3), 727-735 (2012-02-01)
High-molecular-weight, branched N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers were synthesized and conjugated with Fab' fragments of the anti-CD20 antibody, 1F5. This produced multivalent conjugates with varying valency (amount of Fab' per macromolecule) targeted to the B-cell antigen CD20. The apoptotic activity of the
Stefan Hoffmann et al.
Biomacromolecules, 13(3), 652-663 (2012-01-24)
Preclinical in vivo characterization of new polymeric drug conjugate candidates is crucial for understanding the effects of certain chemical modifications on distribution and elimination of these carrier systems, which is the basis for rational drug design. In our study we
Yang Yang et al.
Biomaterials, 33(7), 2260-2271 (2011-12-23)
Galectin-3 (Gal-3), over-expressed on a variety of human tumor cells, is a potential binding site for targeted metastatic prostate cancer therapy. The aim of this study was to develop a G3-C12-mediated drug delivery system based on N-(2-hydroxypropyl) methacrylamide (HPMA) copolymers
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