- Sensitive analysis of blonanserin, a novel antipsychotic agent, in human plasma by ultra-performance liquid chromatography-tandem mass spectrometry.
Sensitive analysis of blonanserin, a novel antipsychotic agent, in human plasma by ultra-performance liquid chromatography-tandem mass spectrometry.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry (2010-10-19)
Tadashi Ogawa, Hideki Hattori, Rina Kaneko, Kenjiro Ito, Masayo Iwai, Yoko Mizutani, Tetsuya Arinobu, Akira Ishii, Osamu Suzuki, Hiroshi Seno
PMID20953055
ABSTRACT
A rapid and sensitive method for analysis of blonanserin in human plasma by ultra-performance liquid chromatography-tandem mass spectrometry is presented. After pretreatment of a plasma sample by solid-phase extraction, blonanserin was analyzed by the system with a C(18) column. This method gave satisfactory recovery rates, reproducibility, and good linearity of calibration curve in the range of 0.01-10.0 ng/mL for quality control samples spiked with blonanserin. The detection limit was as low as 1 pg/mL. This method seems very useful in forensic and clinical toxicology and pharmacokinetic studies.
MATERIALI