- Preparation of 4-aminophenylacetic acid derivatives with promising antimicrobial activity.
Preparation of 4-aminophenylacetic acid derivatives with promising antimicrobial activity.
Acta pharmaceutica (Zagreb, Croatia) (2006-09-01)
Ahmed H Bedair, Fawzy M Ali, Ahmed M El-Agrody, Fathy A Eid, Mohammed A A El-Nassag, Gamal El-Sherbeny
PMID19831277
ABSTRACT
Condensation of 4-aminophenylacetic acid with phthalic anhydride gave (dioxoisoindolin-2-yl)phenylacetic acid (1), which was employed as the key intermediate in the synthesis of title compounds 2-8. The products were characterized by analytical and spectral data (IR, 1H NMR, 13C NMR and mass spectra). Antimicrobial activities were studied and some of the compounds showed promising results.
MATERIALI