- Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor.
Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor.
Science (New York, N.Y.) (1994-05-13)
K H Grabstein, J Eisenman, K Shanebeck, C Rauch, S Srinivasan, V Fung, C Beers, J Richardson, M A Schoenborn, M Ahdieh
PMID8178155
ABSTRACT
A cytokine was identified that stimulated the proliferation of T lymphocytes, and a complementary DNA clone encoding this new T cell growth factor was isolated. The cytokine, designated interleukin-15 (IL-15), is produced by a wide variety of cells and tissues and shares many biological properties with IL-2. Monoclonal antibodies to the beta chain of the IL-2 receptor inhibited the biological activity of IL-15, and IL-15 competed for binding with IL-2, indicating that IL-15 uses components of the IL-2 receptor.
MATERIALI
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Descrizione del prodotto
Sigma-Aldrich
IL-15 human, Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
Sigma-Aldrich
Interleukin-15 human, >97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture