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V900490

Sigma-Aldrich

CHAPSO

Vetec™, reagent grade, ≥98%

Sinonimo/i:

3-([3-Cholamidopropyl]dimethylammonio)-2-hydroxy-1-propanesulfonate

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About This Item

Formula empirica (notazione di Hill):
C32H58N2O8S
Numero CAS:
82473-24-3
Peso molecolare:
630.88
Beilstein:
5842642
Numero MDL:
MFCD00081079
Codice UNSPSC:
12161900
ID PubChem:
329829889

Grado

reagent grade

Descrizione

zwitterionic

Nome Commerciale

Vetec™

Saggio

≥98%

PM

micellar avg mol wt 7000

Numero d'aggregazione

11

CMC

8 mM (20-25°C)

Punto di fusione

184-186 °C (lit.)

Temp. transizione

cloud point 90 °C

Stringa SMILE

[H][C@@]12C[C@H](O)CC[C@]1(C)[C@@]3([H])C[C@H](O)[C@]4(C)[C@]([H])(CC[C@@]4([H])[C@]3([H])[C@H](O)C2)[C@H](C)CCC(=O)NCCC[N+](C)(C)CC(O)CS([O-])(=O)=O

InChI

1S/C32H58N2O8S/c1-20(7-10-29(39)33-13-6-14-34(4,5)18-23(36)19-43(40,41)42)24-8-9-25-30-26(17-28(38)32(24,25)3)31(2)12-11-22(35)15-21(31)16-27(30)37/h20-28,30,35-38H,6-19H2,1-5H3,(H-,33,39,40,41,42)/t20-,21+,22-,23?,24-,25+,26+,27-,28+,30+,31+,32-/m1/s1
GUQQBLRVXOUDTN-XOHPMCGNSA-N

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Applicazioni

A nondenaturing zwitterionic detergent with characteristics similar to CHAPS, although it is more soluble due to a more polar head group. Useful for the solubilization of integral membrane proteins.

Note legali

Vetec is a trademark of Merck KGaA, Darmstadt, Germany

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
WXBC5250V
WXBB1457V
116K5304V
116K5304

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Jenny Frånberg et al.
Biochemistry, 46(25), 7647-7654 (2007-06-01)
Gamma-secretase is important for the development of Alzheimer's disease, since it is a crucial enzyme for the generation of the pathogenic amyloid beta-peptide (Abeta). Most data on gamma-secretase is derived from studies in cell lines overexpressing gamma-secretase components or amyloid
Rachna Ujwal et al.
Journal of visualized experiments : JoVE, 9(59), e3383-e3383 (2012-01-20)
Membrane proteins (MPs) play a critical role in many physiological processes such as pumping specific molecules across the otherwise impermeable membrane bilayer that surrounds all cells and organelles. Alterations in the function of MPs result in many human diseases and
Mako Takami et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(41), 13042-13052 (2009-10-16)
Amyloid beta protein (Abeta), a pathogenic molecule associated with Alzheimer's disease, is produced by gamma-secretase, which cleaves the beta-carboxyl terminal fragment (betaCTF) of beta-amyloid precursor protein in the middle of its transmembrane domain. How the cleavage proceeds within the membrane
Salem Faham et al.
Protein science : a publication of the Protein Society, 14(3), 836-840 (2005-02-04)
We showed previously that high-quality crystals of bacteriorhodopsin (bR) from Halobacterium salinarum can be obtained from bicelle-forming DMPC/CHAPSO mixtures at 37 degrees C. As many membrane proteins are not sufficiently stable for crystallization at this high temperature, we tested whether
L Czerski et al.
Analytical biochemistry, 284(2), 327-333 (2000-08-31)
Bicelles are bilayered discoidal lipid-detergent assemblies which are useful as model membranes. To date, there has been no direct demonstration of functional viability for an integral membrane protein reconstituted into bicelles. In this contribution, the catalytic activity of diacylglycerol kinase
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