1327000

Hydroxychloroquine sulfate

United States Pharmacopeia (USP) Reference Standard

• Sinonimo/i: Hydroxychloroquine sulfate, 7-Chloro-4-[4-(N-ethyl-N-b-hydroxyethylamino)-1-methylbutylamino]quinoline sulfate
• Formula empirica (notazione di Hill): C₁₈H₂₆ClN₃O · H₂SO₄
• Numero CAS: 747-36-4
• Peso molecolare: 433.95
• NACRES: NA.24
• PubChem Substance ID: 329750122
• UNSPSC Code: 41116107
• EC Number: 212-019-3
• MDL number: MFCD00078203

Proprietà

• biological source: synthetic
• grade: pharmaceutical primary standard
• agency: USP
• API family: hydroxychloroquine
• packaging: pkg of 200 mg
• manufacturer/tradename: USP
• storage condition: protect from light
• color: white to off-white
• pH: 3.5-5.5 (1% in aqueous solution, pH <6.0)
• mp: 388.4 °F (198°C; 240°C)
• solubility: chloroform: practically insoluble, ethanol: practically insoluble, ether: practically insoluble, water: soluble
• application(s): pharmaceutical (small molecule)
• format: neat
• SMILES string: OS(O)(=O)=O.CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12
• InChI: 1S/C18H26ClN3O.H2O4S/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18;1-5(2,3)4/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21);(H2,1,2,3,4)
• InChI key: JCBIVZZPXRZKTI-UHFFFAOYSA-N
• Gene Information: human ... TLR7(51284), TLR9(54106)

Descrizione

General description

Find answers to frequently asked questions on USP products in USP FAQs.

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Hydroxychloroquine Sulfate is a salt of hydroxychloroquine (HCQ, Plaquenil), a 4-aminoquinoline based antiviral drug.

Application

Hydroxychloroquine sulfate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

• Hydroxychloroquine Sulfate Tablets
• Hydroxychloroquine Sulfate Compounded Oral Suspension
• Chloroquine Phosphate

Biochem/physiol Actions

Hydroxychloroquine sulfate is an anti-inflammatory (via TNF), disease-modifying antirheumatic drug (DMARD), and a heme polymerase inhibitor.

Hydroxychloroquine sulfate is an anti-inflammatory (via TNF), disease-modifying antirheumatic drug (DMARD), and a heme polymerase inhibitor. It is used in treating malaria.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Informazioni sulla sicurezza

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H315,H319
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
• Classe di stoccaggio: 11 - Combustible Solids
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• pcodes: P264 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P332 + P313