PHL22642

Rotenone

phyproof^® Reference Substance

• Formula empirica (notazione di Hill): C₂₃H₂₂O₆
• Numero CAS: 83-79-4
• Peso molecolare: 394.42
• Beilstein: 6773081
• Numero MDL: MFCD09025614

Proprietà

• Grado: primary reference standard
• Nome Commerciale: phyproof^® Reference Substance
• Saggio: ≥95.0% (HPLC)
• Produttore/marchio commerciale: PhytoLab
• tecniche: HPLC: suitable
• P. eboll.: 210-220 °C/0.5 mmHg (lit.)
• Punto di fusione: 159-164 °C (lit.)
• applicazioni: food and beverages; pharmaceutical
• Formato: neat ()
• Temperatura di conservazione: −20°C
• Stringa SMILE: COc1cc2OCC3Oc4c5C[C@@H](Oc5ccc4C(=O)C3c2cc1OC)C(C)=C
• InChI: 1S/C23H22O6/c1-11(2)16-8-14-15(28-16)6-5-12-22(24)21-13-7-18(25-3)19(26-4)9-17(13)27-10-20(21)29-23(12)14/h5-7,9,16,20-21H,1,8,10H2,2-4H3/t16-,20-,21+/m1/s1; JUVIOZPCNVVQFO-HBGVWJBISA-N

Descrizione

Descrizione generale

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Azioni biochim/fisiol

Rotenone is an inhibitor of mitochondrial electron transport at nicotinamide adenine dinucleotide (NADH):ubiquinone oxidoreductase. It is readily absorbed through the exoskeletons of arthropods, but poorly absorbed cutaneously or from the gastrointestinal tract of mammals. Rotenone acts as a neurotoxic agent which can produce Parkinson-like condition to serve as an animal model for the study of etiology and interventions. The primary mechanism of action of rotenone is complex I inhibition, followed by the generation of oxidative stress and oxidative damage. Because rotenone is lipophilic, it readily penetrates the brain, where it attaches to and inhibits mitochondrial complex I of electron chain transport (ETC).

Note legali

phyproof is a registered trademark of PhytoLab GmbH & Co. KG

Informazioni sulla sicurezza

• Pittogrammi: GHS06,GHS09
• Avvertenze: Danger
• Indicazioni di pericolo: H300 + H330,H315,H319,H335,H410
• Consigli di prudenza: P260 - P264 - P273 - P302 + P352 - P304 + P340 + P310 - P305 + P351 + P338
• Classi di pericolo: Acute Tox. 1 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organi bersaglio: Respiratory system
• Codice della classe di stoccaggio: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe di pericolosità dell'acqua (WGK): WGK 3