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V4765

Sigma-Aldrich

Valnoctamide

≥98% (NMR)

Sinonimo/i:

2-ethyl-3-methyl-pentanamide, Axiquel, Nirvanil

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25 MG
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About This Item

Formula empirica (notazione di Hill):
C8H17NO
Numero CAS:
4171-13-5
Peso molecolare:
143.23
Numero MDL:
MFCD00868184
Codice UNSPSC:
12352200
ID PubChem:
329829054
NACRES:
NA.77

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Saggio

≥98% (NMR)

Stato

powder

Condizioni di stoccaggio

desiccated

Colore

white to off-white

Solubilità

DMSO: 20 mg/mL, clear

Temperatura di conservazione

room temp

Stringa SMILE

CCC(C)C(CC)C(N)=O

InChI

1S/C8H17NO/c1-4-6(3)7(5-2)8(9)10/h6-7H,4-5H2,1-3H3,(H2,9,10)
QRCJOCOSPZMDJY-UHFFFAOYSA-N

Applicazioni

Valnoctamide has been used:
  • as a mood stabilizer to study its anti-cytomegalovirus (anti-CMV) effects in newborn mice brain [1]
  • as a hypnotic sedative to study its cytotoxic effects on oligodendrocyte precursor cells (OPCs) and human oligodendroglioma cell line (HOG) [2]
  • as a mood stabilizer to study its effects on inhibition of human cytomegalovirus [3]

Azioni biochim/fisiol

Valnoctamide exhibits anti-cytomegalovirus (anti-CMV) properties.[1] It has therapeutic effects against status epilepticus (SE) and neuropathic pain. Valnoctamide also shows therapeutic effects against bipolar disorders.[4]
Valproic acid (VPA) and derivatives such as valpromide and valnoctamide are anti-convulsant, mood stabilizing drugs, believed to function as indirect GABA agonists by inhibiting the transamination of GABA.

Caratteristiche e vantaggi

This compound is featured on the Glutamate/GABA Synthesis and Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302

Classi di pericolo

Acute Tox. 4 Oral

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
0000194662
0000194662
0000072974
0000058056
0000058057

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Mood stabilizers inhibit cytomegalovirus infection
Ornaghi S, et al.
Virology, 499(29), 121-135 (2016)
M Bialer
Journal of controlled release : official journal of the Controlled Release Society, 62(1-2), 187-192 (1999-10-16)
Valproic acid (VPA) is one of the major antiepileptic drugs. However, its anticonvulsant potency is less than the other three major antiepileptic drugs. Furthermore, VPA causes two rare but severe side effects: teratogenicity and hepatotoxicity. We utilized pharmacokinetic considerations in
M Radatz et al.
Epilepsy research, 30(1), 41-48 (1998-04-29)
The teratogenic properties of valproic acid (VPA) and its analogues depend to a great extent on their chemical structure. We investigated the structure-teratogenicity relationships of VPA, its structural isomer, valnoctic acid (VCA), and their two amide analogues, valpromide (VPD) and
S Barel et al.
Clinical pharmacology and therapeutics, 61(4), 442-449 (1997-04-01)
To investigate the pharmacokinetics of the four stereoisomers of valnoctamide, a mild tranquilizer endowed with anticonvulsant properties. Racemic valnoctamide, 400 mg, was administered orally to seven healthy subjects and to six patients with epilepsy stabilized with long-term carbamazepine therapy. In
Valnoctamide inhibits cytomegalovirus infection in developing brain and attenuates neurobehavioral dysfunctions and brain abnormalities
Ornaghi S, et al.
The Journal of Neuroscience, 37(29), 6877-6893 (2017)
Visualizza tutti i documenti correlati

Articoli

Glutamate/GABA Synthesis & Metabolism

Glutamine's role in neurotransmitter synthesis and transport highlights its importance in neuronal function and glutamate production.

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