T9533

Transforming Growth Factor-α from rat

powder, synthetic, γ-irradiated, suitable for cell culture

• Sinonimo/i: TGF-α
• Formula empirica (notazione di Hill): C₂₄₄H₃₆₇N₇₁O₇₁S₆
• Numero CAS: 89899-53-6
• Peso molecolare: 5623.35
• Numero MDL: MFCD00082077
• Codice UNSPSC: 12352200

Proprietà

• Origine biologica: synthetic
• Sterilità: γ-irradiated
• Saggio: ~90% (HPLC)
• Forma fisica: powder
• Potenza: 0.02-2.0 ng/mL EC₅₀ (using Balb/MK 1)
• PM: 5.5 kDa
• Composizione: Peptide content, ~80%
• Condizioni di stoccaggio: avoid repeated freeze/thaw cycles
• tecniche: cell culture | mammalian: suitable
• Impurezze: endotoxin, tested
• N° accesso UniProt: P01134
• Temperatura di conservazione: −20°C
• Informazioni sul gene: rat ... Tgfa(24827) , Tgfa(24827)

Descrizione

Amino Acid Sequence

Val-Val-Ser-His-Phe-Asn-Lys-Cys-Pro-Asp-Ser-His-Thr-Gln-Tyr-Cys-Phe-His-Gly-Thr-Cys-Arg-Phe-Leu-Val-Gln-Glu-Glu-Lys-Pro-Ala-Cys-Val-Cys-His-Ser-Gly-Tyr-Val-Gly-Val-Arg-Cys-Glu-His-Ala-Asp-Leu-Leu-Ala [Disulfide Bridges: 8-21; 16-32; 34-43]

Azioni biochim/fisiol

Transforming growth factor-α (TGF-α), is a 5.5 kDa polypeptide containing 50 amino acids in its mature form. It was originally identified as an agent that reversibly confers a transformed phenotype upon normal non-neoplastic cells, such as normal rat kidney fibroblasts. This activity requires the presence of transforming growth factor-β (TGF-β), which potentiates the action of TGF-α via a separate receptor. TGF-α is synthesized by monocytes, keratinocytes and many tissues and tumors. Mice genetically engineered to be lacking TGF-α expression showed no abnormalities except for the detection of a "wavy" hair coat. TGF-α exerts its action through the EGF receptor.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 13 - Non Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)