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T8325

Sigma-Aldrich

TDZD-8

≥98% (HPLC), needles

Sinonimo/i:

4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione

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5 MG
CHF 161.00
25 MG
CHF 494.00

CHF 161.00

Spedizione prevista il01 giugno 2025

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5 MG
CHF 161.00
25 MG
CHF 494.00

About This Item

Formula empirica (notazione di Hill):
C10H10N2O2S
Numero CAS:
327036-89-5
Peso molecolare:
222.26
Numero MDL:
MFCD04973552
Codice UNSPSC:
12352200
ID PubChem:
329826879
NACRES:
NA.77

CHF 161.00

Spedizione prevista il01 giugno 2025

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Saggio

≥98% (HPLC)

Stato

needles

Condizioni di stoccaggio

protect from light

Colore

white

Punto di fusione

63-64.4 °C

Solubilità

DMSO: >10 mg/mL

Temperatura di conservazione

2-8°C

Stringa SMILE

CN1SC(=O)N(Cc2ccccc2)C1=O

InChI

1S/C10H10N2O2S/c1-11-9(13)12(10(14)15-11)7-8-5-3-2-4-6-8/h2-6H,7H2,1H3
JDSJDASOXWCHPN-UHFFFAOYSA-N

Applicazioni

TDZD-8 has been used to study the role of GSK-3 in maintaining MLL leukemia stem cell transcriptional program[1]. TDZD-8 has also been used to analyze its effect on neural functions of the mouse olfactory bulb[2].

Azioni biochim/fisiol

TDZD-8 is a selective inhibitor of GSK-3, a thiadiazolidinone derivative, non-ATP competitive inhibitor of GSK-3β (IC50 = 2 μM). It does not inhibit Cdk-1/cyclin B, CK-II, PKA or PKC at >100 μM. TDZD-8 has been proposed to bind to the kinase site of GSK-3β.
TDZD-8 is a selective inhibitor of GSK-3.

Caratteristiche e vantaggi

This compound is featured on the GSK-3 page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Nota sulla preparazione

TDZD-8 is soluble in DMSO at a concentration that is greater than 10 mg/ml.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
0000191674
113M4756V
102M4618V
090M4633V
098K46022

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Sigma-Aldrich

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Teng Jiang et al.
Inflammation, 41(3), 811-823 (2018-01-25)
As a recently identified susceptibility gene for Alzheimer's disease (AD), triggering receptor expressed on myeloid cells 2 (TREM2) encodes an immune receptor that is uniquely expressed on microglia, functioning as a modulator of microglial functions including phagocytosis and inflammatory response.
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Cell death & disease, 15(1), 73-73 (2024-01-19)
Chronic stress and elevated levels of glucocorticoids (GCs), the main stress hormones, accelerate Alzheimer's disease (AD) onset and progression. A major driver of AD progression is the spreading of pathogenic Tau protein between brain regions, precipitated by neuronal Tau secretion.
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Sevoflurane has been shown to protect against myocardial ischemia/reperfusion (I/R) injury in animals, while its cardioprotection is lost if the ischemic insult is too long. In this study, we proposed a prevailing hypothesis that GSK-3β inhibitor-mediated activation of GSK-3β/β-catenin signaling
Lydia Hannou et al.
Journal of biological rhythms, 33(2), 166-178 (2018-04-20)
NEUROLIGIN-1 (NLGN1) is a postsynaptic adhesion molecule involved in the regulation of glutamatergic transmission. It has been associated with several features of sleep and psychiatric disorders. Our previous work suggested that transcription of the Nlgn1 gene could be regulated by
Zhibin Liang et al.
ACS chemical neuroscience, 9(5), 1166-1183 (2018-01-31)
Glycogen synthase kinase-3β (GSK-3β) is a key enzyme responsible for tau hyperphosphorylation and is a viable therapeutic target of Alzheimer's disease (AD). We developed a new class of GSK-3β inhibitors based on the 6- C-glycosylflavone isoorientin (1). The new inhibitors
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