T7540
Tyrphostin 47
≥98%
Sinonimo/i:
α-Cyano-3,4-dihydroxythiocinnamamide, 3,4-Dihydroxy-α-cyanothiocinnamamide, RG 50864
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About This Item
Formula empirica (notazione di Hill):
C10H8N2O2S
Numero CAS:
Peso molecolare:
220.25
Beilstein:
6508337
Numero MDL:
Codice UNSPSC:
12352200
ID PubChem:
Saggio
≥98%
Potenza
2.4 μM IC50
Solubilità
DMSO: soluble 50 mg/mL, clear, orange
ethanol: soluble
Temperatura di conservazione
2-8°C
Stringa SMILE
NC(=S)\C(=C\c1ccc(O)c(O)c1)C#N
Informazioni sul gene
human ... CDK2(1017) , EGFR(1956)
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Applicazioni
Tyrphostin 47 has been used in LOPAC screening assays to identify human tissue transglutaminase (TGM2) inhibitors. Tyrphostin 47 has also been used to study its effects on hyperpolarization-activated cation current in porcine pacemaker cells.
Azioni biochim/fisiol
Tyrphostin 23 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain,.
EGFR tyrosine kinase inhibitor.
Nota sulla preparazione
Tyrphostin 47 is is soluble in DMSO (50 mg/ml) and yields a clear, orange solution. The product is also soluble in ethanol (40 mM).
Avvertenze
Warning
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Organi bersaglio
Respiratory system
Codice della classe di stoccaggio
13 - Non Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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Jun Takeda et al.
Development, growth & differentiation, 44(6), 501-508 (2002-12-21)
During the development of the chicken proventriculus (glandular stomach), the initially undifferentiated epithelium differentiates into two distinct cell populations: the glandular epithelium, cells of which secrete embryonic chicken pepsinogen (ECPg), and luminal epithelial cells, which express the chicken spasmolytic polypeptide
Yorimasa Ogata et al.
Cell biology international, 27(8), 689-693 (2003-07-18)
Bradykinin (1 microM) and histamine (100 microM) evoked an initial transient increase and a subsequent sustained increase in intracellular Ca(2+) concentration ([Ca(2+)](i)) in fura-2-loaded human gingival fibroblasts, which may be attributed to Ca(2+) release from intracellular stores and Ca(2+) entry
[Stimulating effect of insulin and epidermal growth factor on activity of protein kinase A, glucose 6-phosphate dehydrogenase and glycogen synthetase in skeletal muscles of chickens and chicken embryos].
L A Kuznetsova et al.
Zhurnal evoliutsionnoi biokhimii i fiziologii, 40(4), 325-333 (2004-10-16)
Maribel Diaz-Ricart et al.
Thrombosis research, 121(6), 873-883 (2007-10-02)
Platelet activation leads to signal transduction mechanisms, in which phosphotyrosine proteins play a relevant role. Platelet suspensions were independently activated by collagen and thrombin in the absence and in the presence of two tyrosine kinase inhibitors, tyrphostin 47 and genistein.
Naoki Kimura et al.
Bioconjugate chemistry, 18(6), 1778-1785 (2007-10-24)
The present study reported proof-of-principle for a kinase assay approach that can detect specific peptide phosphorylation events. The method involves attachment of peptides onto commercial aminosilane and polycarbodiimide-coated glass slides, using a newly developed DNattach linker system that consists of
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