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Merck
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T4057

Sigma-Aldrich

Tyrphostin AG 1296

≥98%

Sinonimo/i:

6,7-Dimethoxy-2-phenylquinoxaline

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About This Item

Formula empirica (notazione di Hill):
C16H14N2O2
Numero CAS:
146535-11-7
Peso molecolare:
266.29
Numero MDL:
MFCD00270913
Codice UNSPSC:
12352200
ID PubChem:
329826783

Saggio

≥98%

Forma fisica

powder

Solubilità

methylene chloride: soluble 10 mg/mL
DMSO: soluble

Temperatura di conservazione

2-8°C

Stringa SMILE

COc1cc2ncc(nc2cc1OC)-c3ccccc3

InChI

1S/C16H14N2O2/c1-19-15-8-12-13(9-16(15)20-2)18-14(10-17-12)11-6-4-3-5-7-11/h3-10H,1-2H3
QNOXYUNHIGOWNY-UHFFFAOYSA-N

Azioni biochim/fisiol

Studies have reported that phosphorylation of tyrosine 857 in PDGF β-receptor is the most susceptible to inhibition by tyrphostin AG 12962.
Selective inhibitor of platelet-derived growth factor (PDGF) receptor protein.

Nota sulla preparazione

Tyrphostin AG 1296 is soluble in methylene chloride at 10 mg/ml and is also soluble in DMSO.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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Nathan G Dolloff et al.
Cancer research, 67(2), 555-562 (2007-01-20)
The factors regulating the bone tropism of disseminated prostate cancer cells are still vaguely defined. We report that prostate cancer cells that metastasize to the skeleton respond to human bone marrow with a robust stimulation of the phosphatidylinositol 3-kinase/Akt pathway
Saher Hamed et al.
PloS one, 5(11), e13986-e13986 (2010-11-19)
Autologous transplanted fat has a high resorption rate, providing a clinical challenge for the means to reduce it. Erythropoietin (EPO) has non-hematopoietic targets, and we hypothesized that EPO may improve long-term fat graft survival because it has both pro-angiogenic and
Ruei-Zeng Lin et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(28), 10137-10142 (2014-07-02)
Endothelial colony-forming cells (ECFCs) are endothelial precursors that circulate in peripheral blood. Studies have demonstrated that human ECFCs have robust vasculogenic properties. However, whether ECFCs can exert trophic functions in support of specific stem cells in vivo remains largely unknown.
Susanne Dell et al.
Investigative ophthalmology & visual science, 47(5), 1928-1937 (2006-04-28)
Corneal neovascularization remains an unsolved therapeutic problem. Platelet-derived growth factor (PDGF) is directly linked to vessel formation and stabilization. This study was undertaken to elucidate the mechanisms by which PDGF exerts its effects on corneal angiogenesis. Corneal neovascularization was induced
Kate Chao-Wei Chen et al.
Molecular vision, 13, 374-387 (2007-03-30)
The mitogenic action of PDGF has been shown to associate with reactive oxygen species (ROS) generation, but the mechanism leading to ROS production and subsequent cell proliferation is not clear. We investigated the upstream membrane-bound target proteins involved in PDGF-stimulated
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