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T3202

Sigma-Aldrich

Torsemide

≥98% (HPLC), solid

Sinonimo/i:

Demadex, N-[[(1-Methylethyl)amino]carbonyl]-4-[(3-methylphenyl)amino]-3-pyridinesulfonamide

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About This Item

Formula empirica (notazione di Hill):
C16H20N4O3S
Numero CAS:
56211-40-6
Peso molecolare:
348.42
Numero MDL:
MFCD00866166
Codice UNSPSC:
12352200
ID PubChem:
329826741
NACRES:
NA.77

Saggio

≥98% (HPLC)

Forma fisica

solid

Solubilità

DMSO: soluble 18 mg/mL
H2O: insoluble

Ideatore

Roche

Stringa SMILE

CC(C)NC(=O)NS(=O)(=O)c1cnccc1Nc2cccc(C)c2

InChI

1S/C16H20N4O3S/c1-11(2)18-16(21)20-24(22,23)15-10-17-8-7-14(15)19-13-6-4-5-12(3)9-13/h4-11H,1-3H3,(H,17,19)(H2,18,20,21)
NGBFQHCMQULJNZ-UHFFFAOYSA-N

Informazioni sul gene

human ... SLC12A1(6557)

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Applicazioni

Torsemide has been used as an inhibitor of Na+ Cl- co-transporter in transgenic Arabidopsis thaliana plants1.

Azioni biochim/fisiol

Torsemide functions in the thick ascending limb of the loop of Henle and enhances the excretion of sodium, chloride and water from the luminal side of the cells. Furthermore, torsemide can treat oedematous conditions that are associated with diseases such as liver cirrhosis, kidney disorders and chronic congestive heart failure2.
Torsemide is a loop diuretic of the pyridine-sulfonylurea class with antialdosteronergic properties and inhibitor of the Na+/K+/2Cl- carrier system.

Caratteristiche e vantaggi

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Nota sulla preparazione

Torsemide is soluble in DMSO at 18 mg/ml and is insoluble in water.

Pittogrammi

Health hazardExclamation mark
GHS08,GHS07

Avvertenze

Warning

Indicazioni di pericolo

H319,H361fd

Classi di pericolo

Eye Irrit. 2 - Repr. 2

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

Certificati d'analisi (COA)

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H A Friedel et al.
Drugs, 41(1), 81-103 (1991-01-01)
Torasemide (torsemide) is a high-ceiling loop diuretic which acts on the thick ascending limb of the loop of Henle to promote rapid and marked excretion of water, sodium and chloride. Like furosemide (frusemide), its major site of action is from
Livia Saleh et al.
Plant signaling & behavior, 8(6), e24259-e24259 (2013-04-23)
The involvement of chloride in salt stress symptoms and salt tolerance mechanisms in plants has been less investigated in the past. Therefore, we studied the salt-induced chloride influx in Arabidopsis expressing the GFP-based anion indicator Clomeleon. High salt concentrations induce
J Strobel et al.
Deutsche medizinische Wochenschrift (1946), 136(22), 1207-1210 (2011-05-26)
A 27-year-old woman was admitted to the emergency room because of dyspnoea. Two months earlier she had given birth to a healthy young boy via cesarean section. Computed tomography showed acute embolism in both pulmonary arteries. Chest X-ray and echocardiography
Zarko Jovic et al.
Journal of chromatographic science, 50(4), 324-334 (2012-03-13)
Complete evaluation of chromatographic behavior and establishment of optimal experimental conditions for determination of torasemide and its four impurities are determined by experimental design. Fractional factorial and 3(n) full factorial design were employed for efficient and rapid optimization of liquid
Mark A Oyama et al.
Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology, 13(4), 287-292 (2011-10-28)
Diuretics are a mainstay of therapy in dogs with heart failure. In dogs with advanced heart failure, moderate to high doses of loop diuretics such as furosemide are used with diminishing effects as profound activation of neuroendocrine systems promote signs
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