T3202

Torsemide

≥98% (HPLC), solid

• Sinonimo/i: Demadex, N-[[(1-Methylethyl)amino]carbonyl]-4-[(3-methylphenyl)amino]-3-pyridinesulfonamide
• Formula empirica (notazione di Hill): C₁₆H₂₀N₄O₃S
• Numero CAS: 56211-40-6
• Peso molecolare: 348.42
• NACRES: NA.77
• PubChem Substance ID: 329826741
• UNSPSC Code: 12352200
• MDL number: MFCD00866166
• Assay: ≥98% (HPLC)
• Form: solid

Proprietà

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• solubility: DMSO: soluble 18 mg/mL, H₂O: insoluble
• originator: Roche
• SMILES string: CC(C)NC(=O)NS(=O)(=O)c1cnccc1Nc2cccc(C)c2
• InChI: 1S/C16H20N4O3S/c1-11(2)18-16(21)20-24(22,23)15-10-17-8-7-14(15)19-13-6-4-5-12(3)9-13/h4-11H,1-3H3,(H,17,19)(H2,18,20,21)
• InChI key: NGBFQHCMQULJNZ-UHFFFAOYSA-N
• Gene Information: human ... SLC12A1(6557)

Descrizione

Application

Torsemide has been used as an inhibitor of Na⁺ Cl^- co-transporter in transgenic Arabidopsis thaliana plants¹.

Biochem/physiol Actions

Torsemide functions in the thick ascending limb of the loop of Henle and enhances the excretion of sodium, chloride and water from the luminal side of the cells. Furthermore, torsemide can treat oedematous conditions that are associated with diseases such as liver cirrhosis, kidney disorders and chronic congestive heart failure².

Torsemide is a loop diuretic and inhibitor of the Na⁺/K⁺/2Cl^- carrier system.

Torsemide is a loop diuretic of the pyridine-sulfonylurea class with antialdosteronergic properties and inhibitor of the Na⁺/K⁺/2Cl^- carrier system.

Features and Benefits

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Preparation Note

Torsemide is soluble in DMSO at 18 mg/ml and is insoluble in water.

Informazioni sulla sicurezza

• pictograms: GHS08,GHS07
• signalword: Warning
• hcodes: H319,H361fd
• pcodes: P201 - P202 - P264 - P280 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Eye Irrit. 2 - Repr. 2
• Classe di stoccaggio: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves