T1081
TLQP-21 human
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500 μG
CHF 544.00
1 MG
CHF 941.00
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Cambia visualizzazione
500 μG
CHF 544.00
1 MG
CHF 941.00
About This Item
Codice UNSPSC:
12352200
NACRES:
NA.32
Prodotti consigliati
Stato
lyophilized powder
Livello qualitativo
Colore
white
Solubilità
deionized water: soluble
Condizioni di spedizione
dry ice
Temperatura di conservazione
−20°C
Amino Acid Sequence
H-THR-LEU-GLN-PRO-PRO-SER-ALA-LEU-ARG-ARG-ARG-HIS-TYR-HIS-HIS-ALA-LEU-PRO-PRO-SER-ARG-OH
Descrizione generale
TLQP-21 peptide is a derivative of VGF and is expressed at higher levels in the brain.[1]
Azioni biochim/fisiol
TLQP-21 peptide is involved in the central and peripheral nervous system activities such as regulating reproductive and circadian behaviors, feeding, and body weight. It is also involved in regulating neuropathic pain and peripheral adiposity.[1] TLQP-21 plays a role in stimulating the secretion of insulin and prevents apoptosis of pancreatic cells.[2] It also activates the complement C3a receptor-1 (C3aR1) in the brain.[1]
Stato fisico
Lyophilized from 0.1% aqueous TFA
Altre note
Lyophilized from 0.1% TFA in H2O
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
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Wei Zhang et al.
PloS one, 8(11), e79760-e79760 (2013-11-28)
Hyperglycemia causes oxidative stress that could damage vascular endothelial cells, leading to cardiovascular complications. The Vgf gene was identified as a nerve growth factor-responsive gene, and its protein product, VGF, is characterized by the presence of partially cleaved products. One
A Bartolomucci et al.
Proceedings of the National Academy of Sciences of the United States of America, 103(39), 14584-14589 (2006-09-20)
The vgf gene has been identified as an energy homeostasis regulator. Vgf encodes a 617-aa precursor protein that is processed to yield an incompletely characterized panel of neuropeptides. Until now, it was an unproved assumption that VGF-derived peptides could regulate
Farida El Gaamouch et al.
Molecular neurodegeneration, 15(1), 4-4 (2020-01-12)
Multiomic studies by several groups in the NIH Accelerating Medicines Partnership for Alzheimer's Disease (AMP-AD) identified VGF as a major driver of Alzheimer's disease (AD), also finding that reduced VGF levels correlate with mean amyloid plaque density, Clinical Dementia Rating
C Severini et al.
British journal of pharmacology, 157(6), 984-993 (2009-05-27)
Vgf gene expression has been detected in various endocrine and neuronal cells in the gastrointestinal tract. In this study we investigated the pharmacological activity of different VGF-derived peptides. Among these, TLQP-21, corresponding to the 556-576 fragment of the protein was
Huan Liu et al.
Autophagy, 16(12), 2140-2155 (2020-01-22)
Mesenchymal stem cell (MSC) transplantation has been widely applied as a potential therapeutic for multiple diseases. However, the underlying therapeutic mechanisms are not fully understood, especially the paradox between the low survival rate of transplanted cells and the beneficial therapeutic
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