T103

Trifluperidol hydrochloride

• Sinonimo/i: 4′-Fluoro-4-[4-hydroxy-4-(α,α,α-trifluoro-m tolyl)piperidino]butyrophenone hydrochloride, R 2498, Triperidol
• Formula empirica (notazione di Hill): C₂₂H₂₃F₄NO₂ · HCl
• Numero CAS: 2062-77-3
• Peso molecolare: 445.88
• NACRES: NA.77
• PubChem Substance ID: 24277941
• UNSPSC Code: 12352200
• EC Number: 218-170-1
• MDL number: MFCD00055195
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: desiccated

Proprietà

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• storage condition: desiccated
• color: white to off-white
• solubility: DMSO: ≥20 mg/mL, H₂O: soluble, ethanol: moderately soluble
• SMILES string: Cl.OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c3cccc(c3)C(F)(F)F
• InChI: 1S/C22H23F4NO2.ClH/c23-19-8-6-16(7-9-19)20(28)5-2-12-27-13-10-21(29,11-14-27)17-3-1-4-18(15-17)22(24,25)26;/h1,3-4,6-9,15,29H,2,5,10-14H2;1H
• InChI key: VYGQXRZAHIZHQV-UHFFFAOYSA-N
• Gene Information: human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816)

Descrizione

Application

The interaction of Trifluperidol hydrochloride with NMDA receptors was studied in rat brain buffy coat membranes.

Biochem/physiol Actions

Trifluperidol is a dopamine receptor antagonist with antipsychotic effects used in the treatment of schizophrenia. This neuroleptic penetrates the brain and also affects the glial cells leading to increased release of proinflammatory cytokines. It also alters the metabolism of carbohydrates and amino acids in the brain cortex.

Informazioni sulla sicurezza

• Pittogrammi: GHS06
• Parola di avvertenza: Danger
• Codici di pericolo: H301
• Avvertenze di sicurezza: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Che succede?: WGK 3
• Punto di infiammabilità (°F): Not applicable
• Punto di infiammabilità (°C): Not applicable
• DPI (dispositivi di protezione individuale): Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges