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Key Documents

SRP6383

Sigma-Aldrich

CD319/SLAMF7/CRACC human

recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)

Sinonimo/i:

19A, CS1, FOAP-12

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About This Item

Codice UNSPSC:
12352200
NACRES:
NA.32

Origine biologica

human

Ricombinante

expressed in HEK 293 cells

Tag

6-His tagged (C-terminus)

Saggio

≥95% (SDS-PAGE)

Forma fisica

lyophilized

PM

calculated mol wt 23.2 kDa
observed mol wt 33-48 kDa (DTT-reduced. Protein migrates due to glycosylation. Ser 23 is the predicted N-terminus.)

Confezionamento

pkg of 10 μg
pkg of 50 μg

Impurezze

<1 EU/μg endotoxin (LAL test)

N° accesso UniProt

Q9NQ25

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

Informazioni sul gene

human ... SLAMF7(57823)

Descrizione generale

Research area: IMMUNO AND CKS

SLAM family member 7 (SLAMF7) is also known as CD2-like receptor-activating cytotoxic cells (CRACC), membrane protein FOAP-12, CD antigen CD319, Novel Ly9, Protein 19A, which is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 is expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung and trachea. SLAM F7 (signaling lymphocytic activation molecule F7) receptors are expressed on immune cells such as activated T cells, most B cells, antibody-producing plasma cells and natural killer cells and also on myeloid cells. The SLAMF7 gene is mapped to human chromosome 1q23.3.

Azioni biochim/fisiol

SLAMF7 (signaling lymphocytic activation molecule F7) is considered as a self-ligand which identifies another SLAMF7 expressed on the cell. Apart from immune cells, SLAMF7 is highly expressed in multiple myeloma cells.Isoform 1 of SLAMF7 mediates natural killer (NK) cell activation through a SH2 domain containing 1A (SH2D1A)-independent extracellular signal-regulated extracellular signal-regulated kinases (ERK) mediated pathway. It may play a role in lymphocyte adhesion.Isoform 3 of SLAMF7 does not mediate any NK cell activation.

Stato fisico

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.

Ricostituzione

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Controlling natural killer cell responses: integration of signals for activation and inhibition.
Long E O, et al.
Annual Review of Immunology, 31, 227-258 (2013)
Immune cell inhibition by SLAMF7 is mediated by mechanism requiring Src kinases, CD45 and SHIP-1 defective in multiple myeloma cells.
Guo H, et al.
Molecular and Cellular Biology (2014)
Elotuzumab and daratumumab: emerging new monoclonal antibodies for multiple myeloma.
Kuroda J, et al.
Expert Review of Anticancer Therapy, 13(9), 1081-1088 (2013)
Epigenetic suppression of the immunoregulator MZB1 is associated with the malignant phenotype of gastric cancer.
Kanda M, et al.
International Journal of Cancer. Journal International Du Cancer, 139(10), 2290-2298 (2016)
SLAM receptors and SAP influence lymphocyte interactions, development and function.
Schwartzberg P L, et al.
Nature Reviews: Immunology, 9(1), 39-39 (2009)

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