SRP6312

Alpha 1 Antitrypsin from human plasma

HBsAg, HCV, HBc free, ≥95% (SDS-PAGE)

• Sinonimo/i: AAT, Alpha-1 protease inhibitor, Alpha-1-antiproteinase, PI, Serpin A1
• Codice UNSPSC: 12352202
• NACRES: NA.32

Proprietà

• Origine biologica: human
• Saggio: ≥95% (SDS-PAGE)
• Stato: lyophilized
• Potenza: ≥5.0 I.U. per mg
• PM: 52 kDa
• Confezionamento: pkg of 1 mg
• N° accesso UniProt: P01009
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −20°C
• Informazioni sul gene: human ... Serpin A1(5265)

Descrizione

Descrizione generale

Our Alpha 1 Antitrypsin is a human plasma protein.It is shown to be HBsAg, HCV, HBc free and also negative for anti HIV1 and HIV2 according to FDA approved tests.
The gene AAT (α 1 antitrypsin) is mapped to human chromosome 14q32.1.[1] AAT is an acute-phase plasma protein.[2] It is a water soluble glycoprotein. AAT is mainly secreted by hepatocytes, macrophages, and some cancer cells.[3] AAT is also referred to as Serpin A1.

Applicazioni

AAT (α 1 antitrypsin) from human plasma has been used as a standard to check the presence of AAT in benign and malignant lymphoreticular cells and tissues.[4]

Azioni biochim/fisiol

AAT (α 1 antitrypsin) functions as a serine protease inhibitor with targets like elastase, plasmin, collagenase, thrombin, leucocyte proteases, trypsin, chymotrypsin and plasminogen activator.[3][5] Clinically, its deficiency is associated with two major diseases: pulmonary emphysema and early onset/juvenile hepatic cirrhosis.[3][6] It is elevated in inflammatory conditions, malignancies, liver disease and pregnancy and also after surgical trauma and use of oral contraceptives.[7][8] The simultaneous quantitative determination of AAT and ceruloplasmin permits differential diagnosis of liver afflictions. Rise in AAT occurs as an acute phase response to tissue necrosis and inflammation.[9] It might work as a biomarker for cutaneous squamous cell carcinoma, hepatitis B, insulinomas, NSCLC (non-small cell lung cancer), papillary thyroid carcinoma, lung cancer and breast carcinoma.[10]

Stato fisico

Lyophilized from 30 mM Na Phosphate, pH 6.5 with 300 mM NaCl.

Ricostituzione

In water or aqueous buffer

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 13 - Non Combustible Solids
• Classe di pericolosità dell'acqua (WGK): nwg
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable