SRP5373

INCENP, His tagged human

recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

• Sinonimo/i: FLJ31633, MGC111393
• Codice UNSPSC: 12352202
• NACRES: NA.32

Proprietà

• Ricombinante: expressed in baculovirus infected Sf9 cells
• Saggio: ≥70% (SDS-PAGE)
• Forma fisica: buffered aqueous glycerol solution
• PM: ~19 kDa
• N° accesso NCBI: NM_001040694
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −70°C
• Informazioni sul gene: human ... INCENP(3619)

Descrizione

Descrizione generale

INCENP or inner centromere protein antigens 135/155kDa is a constitutively binding centromere proteins and ′passenger,′ or transiently interacting, proteins. The overexpression of a truncation mutant of chicken INCENP and a chimeric CENPB:INCENP protein in mammalian cell culture disrupted both prometaphase chromosome alignment and completion of cytokinesis. INCENP forms a complex with the evolutionarily conserved family of Aurora B kinases which helps coordinate chromosome segregation, spindle behavior, and cytokinesis during mitosis.

Azioni biochim/fisiol

As part of the chromosomal passenger complex (CPC), inner centromere protein (INCENP) has a role in assembly and stability of the complex. It also aids in the centromere localization of CPC. INCENP has a role in mitosis and associates with microtubules. The protein has been shown to be upregulated in colorectal cancer cell lines.

Stato fisico

Supplied in 50 mM sodium phosphate, pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.2 mM DTT, 25% glycerol.

Nota sulla preparazione

After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles.

Informazioni sulla sicurezza

• Pittogrammi: GHS08,GHS07
• Avvertenze: Danger
• Indicazioni di pericolo: H315,H319,H360D
• Consigli di prudenza: P202 - P264 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Classi di pericolo: Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable