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Merck
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Documenti fondamentali

SRP4838

Sigma-Aldrich

PTEN human

recombinant, expressed in E. coli

Sinonimo/i:

5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, Mutated in multiple advanced cancers 1, PTEN, Phosphatase and tensin homolog, Phosphatidylinositol-3

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About This Item

Numero MDL:
MFCD03458266
Codice UNSPSC:
12352202
NACRES:
NA.32

Origine biologica

human

Ricombinante

expressed in E. coli

Saggio

≥90%

Stato

liquid

PM

~86.0 kDa

Confezionamento

pkg of 5 μg

Condizioni di stoccaggio

avoid repeated freeze/thaw cycles

Impurezze

<0.1 EU/μg

N° accesso NCBI

P60484

Condizioni di spedizione

dry ice

Temperatura di conservazione

−70°C

Informazioni sul gene

human ... PTEN(5728)

Azioni biochim/fisiol

PTEN, a tumor suppressor, has been implicated in a large number of human tumors and is conserved from humans to worms. Characterization of PTEN protein showed that it is a phosphatase that acts on proteins and on 3-phosphorylated phosphoinositides, and can therefore modulate signal-transduction pathways that involve lipid second messengers. Recent results indicate that at least part of its role is to regulate the activity of the serine/threonine kinase AKT/PKB, and thus influence cell survival signaling. Recombinant PTEN is purified by proprietary chromatographic techniques.

Stato fisico

Sterile filtered liquid at 100 μg/ml.

Ricostituzione

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
70338
70238

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Tasneem Bawa-Khalfe et al.
Oncotarget, 8(11), 17651-17664 (2016-11-17)
SUMO protease SENP1 is elevated in multiple carcinomas including prostate cancer (PCa). SENP1 exhibits carcinogenic properties; it promotes androgen receptor-dependent and -independent cell proliferation, stabilizes HIF1α, increases VEGF, and supports angiogenesis. However, mice expressing an androgen-responsive promoter driven SENP1-transgene (SENP1-Tg)
Sarah A Altınoğlu et al.
Biomaterials science, 4(12), 1773-1780 (2016-10-18)
The phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a tumor suppressor, mutated or inactive in a large percentage of human cancers. Restoring PTEN activity in cancer cells through gene therapy has shown to inhibit cell growth and
Bjoern C Froehlich et al.
Proteomics. Clinical applications, 14(5), e2000034-e2000034 (2020-07-10)
Immuno-MALDI (iMALDI) combines immuno-enrichment of biomarkers with MALDI-MS for fast, precise, and specific quantitation, making it a valuable tool for developing clinical assays. iMALDI assays are optimized for the PI3-kinase signaling pathway members phosphatase and tensin homolog (PTEN) and PI3-kinase
Mohammad Imran Khan et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(3), 3198-3211 (2018-11-01)
Growth factor receptor-binding protein 10 (GRB10) is a well-known adaptor protein and a recently identified substrate of the mammalian target of rapamycin (mTOR). Depletion of GRB10 increases insulin sensitivity and overexpression suppresses PI3K/Akt signaling. Because the major reason for the
Junchao Cai et al.
Nature cell biology, 20(4), 465-478 (2018-03-30)
The contribution of autophagy to cancer development remains controversial, largely owing to the fact that autophagy can be tumour suppressive or oncogenic in different biological contexts. Here, we show that in non-small-cell lung cancer (NSCLC), casein kinase 1 alpha 1 (CK1α) suppresses
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