SML4031

BAX Dimer Modulator 19, BDM19

≥98% (HPLC)

• Sinonimo/i: BDM-19, (E)-4-(6-Iodo-2-(3-methylstyryl)-4-oxoquinazolin-3(4H)-yl)benzoic acid, 4-[6-Iodo-2-[2-(3-methylphenyl)ethenyl]-4-oxo-3(4H)-quinazolinyl]benzoic acid, BDM 19, BDM19
• Formula empirica (notazione di Hill): C₂₄H₁₇IN₂O₃
• Numero CAS: 500273-31-4
• Peso molecolare: 508.31
• Numero MDL: MFCD03302943
• Codice UNSPSC: 12352200

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Stato: powder
• Colore: white to beige
• Solubilità: DMSO: 2 mg/mL, clear (Warmed)
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: IC1=CC=C2C(C(N(C(/C=C/C3=CC(C)=CC=C3)=N2)C4=CC=C(C=C4)C(O)=O)=O)=C1
• InChI: CQEADRMBOXGOAE-LFYBBSHMSA-N

Descrizione

Azioni biochim/fisiol

Potent and selective cytosolic BAX dimer modulator that effectively induces apoptosis in cancer cells by selectively modulating inactive BAX.

BDM19, a potent BAX dimer modulator with a Kd of 560 nM, selectively binds to the N-terminal trigger site of inactive BAX, thereby inhibiting its dimerization with an IC50 of 5 μM. By stabilizing the inactive conformation of BAX, BDM-19 allosterically activates it, targeting cells containing cytosolic inactive BAX monomers and dimers. This leads to a dose-dependent translocation of BAX to mitochondria, subsequent cytochrome c release, and induction of apoptosis.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable