SML3755

ZZL-7

≥98% (HPLC)

• Sinonimo/i: Ac-AV-OMe, Ac-Ala-Val-OMe, N-(N-Acetyl-L-alanyl)-L-valine, methyl ester
• Formula empirica (notazione di Hill): C₁₁H₂₀N₂O₄
• Numero CAS: 99141-91-0
• Peso molecolare: 244.29
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD35065263
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: protect from light

Proprietà

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: protect from light
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C

Descrizione

Biochem/physiol Actions

Serotonin transporter (SERT) and neuronal nitric oxide synthase (nNOS) interaction blocker with antidepressant efficacy in vivo.
ZZL-7 is a dipeptide that disrupts the interaction between serotonin transporter (SERT) and neuronal nitric oxide synthase (nNOS) by targeting the groove between the αB helix and βB folding of the nNOS PDZ domain. ZZL-7 decreases 293T cellular SERT-nNOS complex level (post 2h incubation at 1 μM) and demonstrates antidepressant efficacy in wt, but not nNos-/- mice in vivo (10, 20, and 40 mg/kg via intragastric administration or 10 mg/kg via i.p.) without undesirable side effects to the animals.

Informazioni sulla sicurezza

• Classe di stoccaggio: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable