SML3089

MRS-1706

≥98% (HPLC)

• Sinonimo/i: 8-[4-[((4-Acetylphenyl)carbamoylmethyl)oxy]phenyl]-1,3-di(n-propyl)xanthine, MRS 1706, MRS1706, N-(4-Acetylphenyl)-2-(4-(2,6-dioxo-1,3-dipropyl-2,3,6,9-tetrahydro-1H-purin-8-yl)phenoxy)acetamide, N-(4-Acetylphenyl)-2-[4-(2,3,6,9-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy]acetamide
• Formula empirica (notazione di Hill): C₂₇H₂₉N₅O₅
• Numero CAS: 264622-53-9
• Peso molecolare: 503.55
• NACRES: NA.77
• UNSPSC Code: 12352200
• Assay: ≥98% (HPLC)
• Form: powder

Proprietà

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear (warmed)
• storage temp.: 2-8°C
• SMILES string: O=C(COC1=CC=C(C=C1)C2=NC3=C(N2)N(C(N(C3=O)CCC)=O)CCC)NC4=CC=C(C=C4)C(C)=O
• InChI: 1S/C27H29N5O5/c1-4-14-31-25-23(26(35)32(15-5-2)27(31)36)29-24(30-25)19-8-12-21(13-9-19)37-16-22(34)28-20-10-6-18(7-11-20)17(3)33/h6-13H,4-5,14-16H2,1-3H3,(H,28,34)(H,29,30)
• InChI key: ZKUCFFYOQOJLGT-UHFFFAOYSA-N

Descrizione

Biochem/physiol Actions

High-affinity, potent and selective adenosine 2B receptor (A2B) antagonist/inverse agonist.

MRS-1706 is a high-affinity, potent and selective adenosine 2B receptor (A2B) antagonist/inverse agonist (human A1/A2A/A2B/A3 Ki = 157/112/1.39/230 nM; rat A1/A2A Ki = 37.6/548 nM). MRS-1706 (20 nM), but not the A2A antagonist SCH 58261 (20 nM), completely blocks the enhancement of electrically evoked tritium overflow from isolated rat tail artery by 10 μM adenosine receptor agonist NECA in the presence of 30 nM A1 antagonist DPCPX.

Informazioni sulla sicurezza

• Classe di stoccaggio: 11 - Combustible Solids
• Che succede?: WGK 3
• Punto di infiammabilità (°F): Not applicable
• Punto di infiammabilità (°C): Not applicable