Loviride is an orally available, potent and selective inhibitor of reverse transcriptase HIV-1 that inhibits HIV replication in cells. Also, loviride inhibits replication of HIV-2 and SIV in cells.
Orally available, potent and selective inhibitor of reverse transcriptase HIV-1 that inhibits HIV replication in cells
International journal of pharmaceutics, 537(1-2), 22-29 (2017-12-16)
In view of the increasing interest of pharmaceutical companies for cell- and tissue-free models to implement permeation into formulation testing, this study explored the capability of an artificial membrane insert system (AMI-system) as predictive tool to evaluate the performance of
AIDS (London, England), 13(12), 1477-1483 (1999-08-28)
After the initial discovery of 1-(2-hydroxyethoxymethyl)-6-(phenylthio)thymine (HEPT) and tetrahydroimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one and thione (TIBO) derivatives, several other non-nucleoside reverse transcriptase (RT) inhibitors (NNRTI), including nevirapine (BI-RG-587), pyridinone derivatives (L-696,229 and L-697,661), delavirdine (U-90152), alpha-anilinophenylacetamides (alpha-APA) and various other classes of NNRTI have
Proceedings of the National Academy of Sciences of the United States of America, 90(5), 1711-1715 (1993-03-01)
In vitro evaluation of a large chemical library of pharmacologically acceptable prototype compounds in a high-capacity, cellular-based screening system has led to the discovery of another family of human immunodeficiency virus type 1 (HIV-1) inhibitors. Through optimization of a lead
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