SML2801

Isoforskolin

≥95% (HPLC)

• Sinonimo/i: 6-Acetyl-7-deacetylforskolin, (3R,6S,6aS)-6-(acetyloxy)-3-ethenyldodecahydro-5S,10S,10bS-trihydroxy-3,4aR,7,7,10aR-pentamethyl-1H-naphtho[2,1-b]pyran-1-one, Coleonol B, 6β-Acetoxy-1α,7β,9α-trihydroxy-8,13-epoxy-labd-14-en-11-one, Isoforskolin
• Formula empirica (notazione di Hill): C₂₂H₃₄O₇
• Numero CAS: 64657-21-2
• Peso molecolare: 410.50
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00078929
• Assay: ≥95% (HPLC)
• Form: powder

Proprietà

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: powder
• optical activity: [α]/D -8 to -5°, c = 0.5 in chloroform-d
• color: white to beige
• solubility: DMF:H₂O (9:1): 2 mg/mL, clear
• storage temp.: −20°C
• SMILES string: CC(=O)O[C@@H]1[C@H](O)[C@@]2(C)O[C@](C)(CC(=O)[C@]2(O)[C@@]3(C)[C@@H](O)CCC(C)(C)C13)C=C
• InChI: 1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(28-12(2)23)17(26)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16?,17-,19-,20-,21+,22-/m0/s1
• InChI key: CLOQVZCSBYBUPB-VDCUXWMXSA-N

Descrizione

Biochem/physiol Actions

Isoforskolin is a naturally occurring diterpene with anti-inflammatory activity. It has been shown to downregulate the expression of proinflammatory compounds. In an experimental mouse model of Lyme Disease induced arthritis isoforskolin downregulated the transcription and expression of TNF-α and IL-6 induced by recombinant Borrelia burgdorferi basic membrane protein A (rBmpA). In a rat asthmatic model isoforskolin down-regulated production of transforming growth factor β1 (TGF-β1) and interleukin-1β (IL-1β) which was accompanied by inhibition of inflammation and airway remodeling.

Informazioni sulla sicurezza

• Parola di avvertenza: Warning
• Pittogrammi: GHS07
• Codici di pericolo: H312
• Avvertenze di sicurezza: P280 - P302 + P352 + P312 - P362 + P364 - P501
• Hazard Classifications: Acute Tox. 4 Dermal
• Classe di stoccaggio: 11 - Combustible Solids
• Che succede?: WGK 3